ArticleMediators of inflammation2019
Butyrate Enhances Desensitization Induced by Oral Immunotherapy in Cow's Milk Allergic Mice.
Article in Mediators of inflammation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 38 citations in OpenAlex.
- Article
- Harnessing and delivering microbial metabolites as therapeutics via advanced pharmaceutical approaches.Pharmacology & therapeutics · 2024Review
- Interactions of human milk oligosaccharides with the immune system.Frontiers in immunology · 2024Review
- The potential of live biotherapeutic products in allergic disease: current findings and future directions.Frontiers in microbiomes · 2024Review
- Review
- Nutritional Strategies for the Prevention and Management of Cow's Milk Allergy in the Pediatric Age.Nutrients · 2023Review
- Do advanced glycation end products contribute to food allergy?Frontiers in allergy · 2023Review
- Preclinical evaluation of alternatives to oral immunotherapy for food allergies.Frontiers in allergy · 2023Review
- Recent Research and Application Prospect of Functional Oligosaccharides on Intestinal Disease Treatment.Molecules (Basel, Switzerland) · 2022Review
- Insights into Microbiome and Metabolic Signatures of Children Undergoing Peanut Oral Immunotherapy.Children (Basel, Switzerland) · 2022Article
- A Non-Invasive Neonatal Signature Predicts Later Development of Atopic Diseases.Journal of clinical medicine · 2022Article
- Evaluation of Stool Short Chain Fatty Acids Profiles in the First Year of Life With Childhood Atopy-Related Outcomes.Frontiers in allergy · 2022Article
- A2 adenosine receptor contributes to the development of cow's milk protein allergy via regulating regulatory T cells.Iranian journal of basic medical sciences · 2021Article
- Review
- Butyrate: A Link between Early Life Nutrition and Gut Microbiome in the Development of Food Allergy.Life (Basel, Switzerland) · 2021Review
- Immunonutrition for Pediatric Patients With Cow's Milk Allergy: How Early Interventions Could Impact Long-Term Outcomes.Frontiers in allergy · 2021Review
- Strategies and Future Opportunities for the Prevention, Diagnosis, and Management of Cow Milk Allergy.Frontiers in immunology · 2021Review
- Gut Microbiome Modulation for Preventing and Treating Pediatric Food Allergies.International journal of molecular sciences · 2020Review
- The Role of the Microbiome in Food Allergy: A Review.Children (Basel, Switzerland) · 2020Review
- Free Amino Acids in Human Milk: A Potential Role for Glutamine and Glutamate in the Protection Against Neonatal Allergies and Infections.Frontiers in immunology · 2020Review
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn previous studies, we showed that a fructo-oligosaccharide- (FOS-) supplemented diet enhanced oral immunotherapy (OIT) efficacy in a mouse model for cow's milk allergy. Fermentation of FOS by intestinal bacteria leads to production of short-chain fatty acids (SCFA) including butyrate.
aimTo investigate the contribution of butyrate in the enhanced efficacy of OIT + FOS.
methodsC3H/HeOuJ mice were sensitized and received OIT with or without FOS or butyrate supplementation. After treatment, whole blood was collected to conduct a basophil activation test (BAT) and allergen challenges were performed to measure acute allergic symptoms. CD4 + CD25 + regulatory T cells (Tregs) were isolated from treated mice or differentiated
resultsAllergen-induced basophil activation was reduced in OIT + butyrate samples compared to OIT. Accordingly, the acute allergic skin response and mast cell degranulation upon challenge were reduced in OIT + butyrate and OIT + FOS mice compared to sensitized controls. Butyrate was increased in the cecum content of OIT + FOS mice compared to OIT mice and sensitized controls. Treg-mediated BMMC suppression was enhanced after
conclusionButyrate supplementation enhanced OIT-induced desensitization of basophils and mast cells and Treg functionality. Only OIT + FOS treatment induced potential microbial alterations, shown by increased butyrate levels in cecum content. Both butyrate and FOS are promising candidates to improve OIT efficacy in human studies to treat food allergies.
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Registered trials
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