ArticleClinical, cosmetic and investigational dermatology2019
Evaluation of serum levels of neurotrophin 4 and brain-derived nerve growth factor in uremic pruritus patients.
Article in Clinical, cosmetic and investigational dermatology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 20 citations in OpenAlex.
- Improving immune function and mitochondrial health in patients undergoing hemodialysis: benefits of combining high-flux dialysis with hemoperfusion.Frontiers in medicine · 2026Article
- Patient-Reported Outcome Measures in CKD-Associated Pruritus: A Systematic Review.Kidney medicine · 2025Review
- Nomogram to Estimate the Risk of Chronic Kidney Disease-Associated Pruritus in Patients with End-Stage Renal Disease Undergoing Peritoneal Dialysis: Model Development and Validation Study.Blood purification · 2024Article
- Neurotrophin-4 and Brain-Derived Neurotrophic Factor Serum Levels in Renal Transplant Recipients with Chronic Pruritus.Dermatology and therapy · 2023Article
- Itch: from the skin to the brain - peripheral and central neural sensitization in chronic itch.Frontiers in molecular neuroscience · 2023Review
- Elevated Level of Serum Neurotrophin-4, but Not of Brain-Derived Neurotrophic Factor, in Patients with Chronic Kidney Disease-Associated Pruritus.Journal of clinical medicine · 2022Article
- Lichen Simplex Chronicus Itch: An Update.Acta dermato-venereologica · 2022Article
- Chronic Kidney Disease-Associated Pruritus: A Glance at Novel and Lesser-Known Treatments.Cureus · 2022Review
- The Impact of Physical Exercise on the Circulating Levels of BDNF and NT 4/5: A Review.International journal of molecular sciences · 2021Review
- Chronic Kidney Disease-Associated Pruritus.Toxins · 2021Review
- Chronic Intractable Pruritus in Chronic Kidney Disease Patients: Prevalence, Impact, and Management Challenges - A Narrative Review.Therapeutics and clinical risk management · 2021Review
- More than a skin disease: stress, depression, anxiety levels, and serum neurotrophins in lichen simplex chronicus.Anais brasileiros de dermatologiaArticle
- Chronic kidney disease and itch.Itch (Philadelphia, Pa.)Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPruritus is a common symptom in end-stage renal failure. Many patients suffer from this severe distressing symptom. Although several factors have been postulated to explain uremic pruritus, there is not any conclusive evidence for one of these factors.
objectivesWe aimed to evaluate serum levels of brain-derived nerve growth factor (BDNF), neurotrophin-4 (NT-4), serum calcium, phosphors and parathyroid hormone in uremic patients with pruritus and without pruritus compared to control subjects.
methodsOne hundred twenty patients suffering from renal failure and 60 healthy subjects were included in the study. Serum BDNF and NT4 levels were determined by ELISA. The serum calcium, phosphorus, parathyroid hormone and hemoglobin were also evaluated.
resultsSerum BDNF was significantly higher in uremic patients with pruritus (
conclusionThe present study shows that NT-4 level is increased in the serum of uremic patients with pruritus and there was a significant correlation between NT-4 and severity of pruritus suggesting that NT-4 may have a role in uremic pruritus.
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Registered trials
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