Evidence map›Paper›PMID 30799695›Full record

ArticleMolecular pain

Inhibiting STAT3 in a murine model of human breast cancer-induced bone pain delays the onset of nociception.

Katja Linher-Melville, Manu Sharma, Peter Nakhla, Elena Kum, Robert Ungard, Ji Park, David Rosa, Patrick Gunning, Gurmit Singh

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular pain. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Katja Linher-Melville1 Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.
Manu Sharma1 Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.
Peter Nakhla1 Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.
Elena Kum1 Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.
Robert Ungard1 Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.
Ji Park2 Department of Chemical and Physical Sciences, University of Toronto Mississauga, Mississauga, Ontario, Canada.
David Rosa2 Department of Chemical and Physical Sciences, University of Toronto Mississauga, Mississauga, Ontario, Canada.
Patrick Gunning2 Department of Chemical and Physical Sciences, University of Toronto Mississauga, Mississauga, Ontario, Canada.
Gurmit Singh1 Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.

Funding

CIHR
6 · The paper itself

Abstract

Aggressive breast cancer subtypes utilize system x

Indexed as

AnimalsAntineoplastic Combined Chemotherapy ProtocolsBone and BonesBone NeoplasmsBreast NeoplasmsCancer PainCarcinomaCell Line, TumorCytokinesDisease Models, AnimalExploratory BehaviorFemaleGene Expression Regulation, NeoplasticHumansHyperalgesiaMaleCytokinesSTAT3 Transcription Factorcancer paincytokinesglutamateSTAT3system x

Identifiers

PMID30799695
PMCPMC6329039

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.