Evidence map›Paper›PMID 30799593›Full record

ArticleYonsei medical journal2019

MiR-590 Inhibits Endothelial Cell Apoptosis by Inactivating the TLR4/NF-κB Pathway in Atherosclerosis.

Lei Yang, Chuanyu Gao

RetractedOpen access · goldAbstract readRetracted Publication
In one paragraph

Article in Yonsei medical journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 37 citations in OpenAlex.

  1. Article
  2. Review
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  11. Unveiling ncRNA regulatory axes in atherosclerosis progression.Clinical and translational medicine · 2020
    Review
  12. Oxidative Stress in Ischemic Heart Disease.Oxidative medicine and cellular longevity · 2020
    Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Lei YangDepartment of Emergency, Zhengzhou University People's Hospital, Zhengzhou, China.ORCID https://orcid.org/0000-0002-9891-6126
Chuanyu GaoDepartment of Coronary Heart Disease, Zhengzhou University People's Hospital, Fuwai Central China Cardiovascular Hospital, Zhengzhou, China. alonewoof@126.com.ORCID https://orcid.org/0000-0002-5362-3573
Zhengzhou Central Hospital · CNZhengzhou People's Hospital · CN

Funding

Henan Provincial Science and Technology Department 162102310205
6 · The paper itself

Abstract

purposePrevious study has well documented the anti-apoptotic effects of miR-590 on oxidized low-density lipoprotein (ox-LDL)-treated endothelial cells (ECs). However, the mechanism underlying the anti-apoptotic effects of miR-590 in ox-LDL-treated ECs remains to be further addressed. MATERIALS AND

methodsApoE

resultsmiR-590 was downregulated in the aorta tissues from HFD-fed apoE

conclusionmiR-590 promoted proliferation and blocked ox-LDL-induced apoptosis in HAECs through inhibition of the TLR4/NF-κB pathway.

Indexed as

ApoptosisAnimalsAortaApolipoproteins EAtherosclerosisBase SequenceCell ProliferationDiet, High-FatDown-RegulationEndothelial CellsHumansLipoproteins, LDLMaleMice, Inbred C57BLMicroRNAsNF-kappa BApolipoproteins ELipoproteins, LDLMicroRNAsMIRN590 microRNA, humanMIRN590 microRNA, mouseNF-kappa Boxidized low density lipoproteinToll-Like Receptor 4ApoE(-/-) miceatherosclerosisMiR-590ox-LDLTLR4/NF-κB pathway

Identifiers

PMID30799593
PMCPMC6391523
OpenAlexW2918042114

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.