ArticleCurrent biology : CB2019
Ectopic Germ Cells Can Induce Niche-like Enwrapment by Neighboring Body Wall Muscle.
Article in Current biology : CB, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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24 citing papers in PubMed, 28 citations in OpenAlex.
- Pre-dauer starvation rapidly and reversibly reduces niche proliferative signaling to the Caenorhabditis elegans germ line.Development (Cambridge, England) · 2026Article
- Non-autonomy of age-related morphological changes in the C. elegans germline stem cell niche.Development (Cambridge, England) · 2025Article
- Non-autonomy of age-related morphological changes in thebioRxiv : the preprint server for biology · 2025Article
- MIG-21 interacts with Wnt and Netrin signaling in gonad migration in C. elegans.PLoS genetics · 2025Article
- MIG-21 is a novel regulator of Wnt and Netrin signaling in gonad migration identified from published scRNA-seq data and functionally validated inbioRxiv : the preprint server for biology · 2025Article
- Article
- A role for organ level dynamics in morphogenesis of the C. elegans hermaphrodite distal tip cell.Development (Cambridge, England) · 2024Article
- Germline loss in C. elegans enhances longevity by disrupting adhesion between niche and stem cells.The EMBO journal · 2024Article
- Notch signaling without the APH-2/nicastrin subunit of gamma secretase in Caenorhabditis elegans germline stem cells.Genetics · 2024Article
- The Rac pathway prevents cell fragmentation in a nonprotrusively migrating leader cell during C. elegans gonad organogenesis.Current biology : CB · 2024Article
- The roles of TGFβ and serotonin signaling in regulating proliferation of oocyte precursors and germline aging.bioRxiv : the preprint server for biology · 2024Article
- Getting there in one piece: The Rac pathway prevents cell fragmentation in a nonprotrusively migrating leader cell during organogenesis.bioRxiv : the preprint server for biology · 2023Article
- Hemicentin-mediated type IV collagen assembly strengthens juxtaposed basement membrane linkage.The Journal of cell biology · 2023Article
- Analysis of the C. elegans Germline Stem Cell Pool.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Oogenesis in Caenorhabditis elegans.Sexual development : genetics, molecular biology, evolution, endocrinology, embryology, and pathology of sex determination and differentiation · 2023Review
- A light sheet fluorescence microscopy protocol forFrontiers in cell and developmental biology · 2022Article
- AnmicroPublication biology · 2022Article
- Molecular basis of reproductive senescence: insights from model organisms.Journal of assisted reproduction and genetics · 2021Review
- A Genome-Wide RNAi Screen for Enhancers of a Germline Tumor Phenotype Caused by Elevated GLP-1/Notch Signaling inG3 (Bethesda, Md.) · 2020Article
- Recent Advances in the Genetic, Anatomical, and Environmental Regulation of theJournal of developmental biology · 2020Review
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7 authors at 3 institutions in 1 country.
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Abstract
Niche cell enwrapment of stem cells and their differentiating progeny is common and provides a specialized signaling and protective environment. Elucidating the mechanisms underlying enwrapment behavior has important basic and clinical significance in not only understanding how niches are formed and maintained but also how they can be engineered and how they are misregulated in human pathologies, such as cancer. Previous work in C. elegans found that, when germ cells, which are enwrapped by somatic gonadal niche cells, are freed into the body cavity, they embed into other tissues. We investigated this phenomenon using live-cell imaging and discovered that ectopic germ cells preferentially induce body-wall muscle to extend cellular processes that enwrap the germ cells, the extent of which was strikingly similar to the distal tip cell (DTC)-germ stem cell niche. Enwrapment was specific for escaped germ cells, and genetic analysis revealed it did not depend on pathways that control cell death and engulfment or muscle arm extension. Instead, using a large-scale RNAi screen and GFP knockin strains, we discovered that the enwrapping behavior of muscle relied upon the same suite of cell-cell adhesion molecules that functioned in the endogenous niche: the C. elegans E-cadherin HMR-1, its intracellular associates α-catenin (HMP-1) and β-catenin (HMP-2), and the L1CAM protein SAX-7. This ectopic niche-like behavior resembles the seed-and-soil model of cancer metastasis and offers a new model to understand factors regulating ectopic niche formation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.