Evidence map›Paper›PMID 30799029›Full record

ArticleAmerican journal of kidney diseases : the official journal of the National Kidney Foundation2019

Renal Hemodynamic Function and RAAS Activation Over the Natural History of Type 1 Diabetes.

Yuliya Lytvyn, Petter Bjornstad, Julie A Lovshin, Genevieve Boulet, Mohammed A Farooqi, Vesta Lai, Josephine Tse, Leslie Cham, Leif E Lovblom, Alanna Weisman and 8 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of kidney diseases : the official journal of the National Kidney Foundation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 21 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors at 5 institutions in 3 countries.

Yuliya LytvynDivision of Nephrology, Department of Medicine, Toronto General Hospital, University of Toronto, Toronto, Ontario, Canada. Electronic address: julia.lytvyn@mail.utoronto.ca.
Petter BjornstadDivision of Endocrinology, Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO.
Julie A LovshinDivision of Endocrinology and Metabolism, Department of Medicine, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada.
Genevieve BouletDivision of Endocrinology and Metabolism, Department of Medicine, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada.
Mohammed A FarooqiDivision of Endocrinology and Metabolism, Department of Medicine, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada.
Vesta LaiDivision of Nephrology, Department of Medicine, Toronto General Hospital, University of Toronto, Toronto, Ontario, Canada.
Josephine TseDivision of Nephrology, Department of Medicine, Toronto General Hospital, University of Toronto, Toronto, Ontario, Canada.
Leslie ChamDivision of Nephrology, Department of Medicine, Toronto General Hospital, University of Toronto, Toronto, Ontario, Canada.
Leif E LovblomLunenfeld-Tanenbaum Research Institute, Mount Sounai Hospital, University of Toronto, Toronto, Ontario, Canada.
Alanna WeismanDivision of Endocrinology and Metabolism, Department of Medicine, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada.
Hillary A KeenanMount Sinai Hospital, Toronto, Ontario, Canada; Genzyme, Cambridge, MA.
Michael H BrentDepartment of Ophthalmology and Vision Sciences, University of Toronto, Toronto, Canada; Department of Medicine, University of Toronto, Toronto, Canada.
Narinder PaulDivision of Cardiothoracic Radiology, Joint Department of Medical Imaging, University Health Network, Toronto, Canada.
Vera BrilDivision of Neurology, Department of Medicine, University of Toronto, Toronto, Canada; Ellen and Martin Prosserman Centre for Neuromuscular Diseases, Division of Neurology, Department of Medicine, University Health Network, University of Toronto, Toronto, Canada; Institute for Research and Medical Consultations, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia.
Andrew AdvaniKeenan Research Centre for Biomedical Science and Li Ka Shing Knowledge Institute of St. Michael's Hospital, Ontario, Canada.
Etienne SochettDivision of Pediatric Endocrinology, Department of Pediatrics, University of Toronto, Ontario, Canada.
Bruce A PerkinsDivision of Endocrinology and Metabolism, Department of Medicine, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada.
David Z I CherneyDivision of Nephrology, Department of Medicine, Toronto General Hospital, University of Toronto, Toronto, Ontario, Canada.
University of Toronto · CAMount Sinai Hospital · CAUniversity Health Network · CASt. Michael's Hospital · CAUniversity of Colorado Denver · US

Funding

Training Program in Diabetes ResearchT32DK063687 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI Andrea Steck · 2002 to 2026
$5.2M
Renal HEIR Study: Renal Hemodynamics, Energetics and Insulin Resistance in Youth Onset Type 2 Diabetes StudyK23DK116720 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI BJORNSTAD, PETTER · 2018 to 2022
$963k
NIDDK NIH HHS K23 DK116720NIDDK NIH HHS T32 DK063687
6 · The paper itself

Abstract

RATIONALE &

objectiveThe renin-angiotensin-aldosterone system (RAAS) is associated with renal and cardiovascular disease in diabetes. Unfortunately, early RAAS blockade in patients with type 1 diabetes mellitus (T1DM) does not prevent the development of complications. We sought to examine the role of hyperfiltration and RAAS activation across a wide range of T1DM duration to better understand renal hemodynamic status in patients with T1DM. STUDY

designPost hoc analysis of blood samples. SETTING &

participants148 Canadian patients with T1DM: 28 adolescents (aged 16.2±2.0 years), 54 young adults (25.4±5.6 years), and 66 older adults (65.7±7.5 years) studied in a clinical investigation unit. EXPOSURE: Angiotensin II infusion (1ng/kg/min; a measure of RAAS activation) during a euglycemic clamp. OUTCOMES: Glomerular filtration rate measured using inulin clearance, effective renal plasma flow measured using para-aminohippurate, afferent (R

resultsIn a stepwise fashion, glomerular filtration rate, effective renal plasma flow, and glomerular hydrostatic pressure were higher, while renal vascular resistance and R LIMITATIONS: Homogeneous study participants limit the generalizability of findings to other populations. Studying older adult participants with T1DM may be associated with a survivorship bias.

conclusionsA state of relatively low RAAS activity and predominant afferent dilation rather than efferent constriction characterize early adolescents and young adults with T1DM. This state of endogenous RAAS inactivity in early T1DM may explain why pharmacologic blockade of this neurohormonal system is often ineffective in reducing kidney disease progression in this setting. Older adults with long-standing T1DM who have predominant afferent constriction and RAAS activation may experience renoprotection from therapies that target the afferent arteriole. Further work is required to understand the potential role of non-RAAS pharmacologic agents that target R

Indexed as

AdolescentAdultAgedAge FactorsAngiotensin IICanadaCohort StudiesDiabetes Mellitus, Type 1FemaleFollow-Up StudiesGlomerular Filtration RateHemodynamicsHumansMaleMiddle AgedProspective StudiesAngiotensin IIageangiotensin II infusiondiabetes durationdiabetic nephropathydisease progressionGomez equationhyperfiltrationRAAS inhibitorrenal hemodynamic functionrenin angiotensin aldosterone system (RAAS)T1DM vintageType 1 diabetes mellitus (T1DM)

Identifiers

PMID30799029
PMCPMC7082148
OpenAlexW2916044705

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.