Evidence map›Paper›PMID 30798657›Full record

ArticleJournal of the International Association of Providers of AIDS Care

Why Maximizing Quality-Adjusted Life Years, rather than Reducing HIV Incidence, Must Remain Our Objective in Addressing the HIV/AIDS Epidemic.

Bohdan Nosyk, Jeong Eun Min, Xiao Zang, Daniel J Feaster, Lisa Metsch, Brandon D L Marshall, Carlos Del Rio, Reuben Granich, Bruce R Schackman, Julio S G Montaner

Abstract read
In one paragraph

Article in Journal of the International Association of Providers of AIDS Care. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Bohdan Nosyk1 BC Centre for Excellence in HIV/AIDS, Vancouver, British Columbia, Canada.ORCID 0000-0003-2513-3718
Jeong Eun Min1 BC Centre for Excellence in HIV/AIDS, Vancouver, British Columbia, Canada.
Xiao Zang1 BC Centre for Excellence in HIV/AIDS, Vancouver, British Columbia, Canada.
Daniel J Feaster3 Department of Epidemiology and Public Health, Center for Family Studies, Leonard M. Miller School of Medicine, University of Miami, Miami, FL, USA.
Lisa Metsch4 Department of Sociomedical Sciences, Mailman School of Public Health, Columbia University, New York, NY, USA.
Brandon D L Marshall5 Department of Epidemiology, Brown School of Public Health, Providence, RI, USA.ORCID 0000-0002-0134-7052
Carlos Del Rio6 Hubert Department of Global Health, Emory Center for AIDS Research, Rollins School of Public Health of Emory University, Atlanta, GA, USA.
Reuben Granich7 Independent Public Health Consultant, Washington, DC, USA.
Bruce R Schackman8 Weill Cornell Medical College, New York, NY, USA.
Julio S G Montaner1 BC Centre for Excellence in HIV/AIDS, Vancouver, British Columbia, Canada.

Funding

Localized economic modeling to support implementation of the Ending the HIV Epidemic initiativeR01DA041747 · NIDA · SIMON FRASER UNIVERSITY · PI NOSYK, BOHDAN · 2016 to 2025
$5.5M
NIDA NIH HHS R01 DA041747
6 · The paper itself

Abstract

With efficacious behavioral, biomedical, and structural interventions available, combination implementation strategies are being implemented to combat HIV/AIDS across settings internationally. However, priority statements from national and international bodies make it unclear whether the objective should be the reduction in HIV incidence or the maximization of health, most commonly measured with quality-adjusted life years (QALYs). Building off a model-based evaluation of HIV care interventions in British Columbia, Canada, we compare the optimal sets of interventions that would be identified using HIV infections averted, and QALYs as the primary outcome in a cost-effectiveness analysis. We found an explicit focus on averting new infections undervalues the health benefits derived from antiretroviral therapy, resulting in suboptimal and potentially harmful funding recommendations.

Indexed as

Cost-Benefit AnalysisQuality-Adjusted Life YearsAcquired Immunodeficiency SyndromeAnti-HIV AgentsAntiretroviral Therapy, Highly ActiveBritish ColumbiaHealth Care CostsHIVHIV InfectionsHumansIncidenceModels, EconomicAnti-HIV Agentseconomic evaluationeconomic modelHIVquality-adjusted life years

Identifiers

PMID30798657
PMCPMC6457342

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.