Evidence map›Paper›PMID 30798633›Full record

ArticleDrug delivery2019

Magnetic aerosol drug targeting in lung cancer therapy using permanent magnet.

Mohammad K D Manshadi, Mahsa Saadat, Mehdi Mohammadi, Reza Kamali, Milad Shamsi, Mozhgan Naseh, Amir Sanati-Nezhad

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Drug delivery, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 47 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Review
  6. Review
  7. Coupling magnetic torque and force for colloidal microbot assembly and manipulation.Advanced intelligent systems (Weinheim an der Bergstrasse, Germany) · 2023
    Article
  8. Article
  9. Review
  10. Article
  11. Magnetic particle targeting for diagnosis and therapy of lung cancers.Journal of controlled release : official journal of the Controlled Release Society · 2020
    Review
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Mohammad K D Manshadia Department of Mechanical and Manufacturing Engineering , University of Calgary , Calgary , Alberta , Canada.
Mahsa Saadatb Department of Chemical Engineering, College of Engineering , Shahid Bahonar University of Kerman , Kerman , Iran.
Mehdi Mohammadia Department of Mechanical and Manufacturing Engineering , University of Calgary , Calgary , Alberta , Canada.
Reza Kamalie Department of Mechanical Engineering , Shiraz University , Shiraz , Iran.
Milad Shamsid Center for Bioengineering Research and Education , University of Calgary , Calgary , Alberta , Canada.
Mozhgan Naseha Department of Mechanical and Manufacturing Engineering , University of Calgary , Calgary , Alberta , Canada.
Amir Sanati-Nezhada Department of Mechanical and Manufacturing Engineering , University of Calgary , Calgary , Alberta , Canada.ORCID http://orcid.org/0000-0002-2309-2388
University of Calgary · CAShahid Bahonar University of Kerman · IRShiraz University · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Primary bronchial cancer accounts for almost 20% of all cancer death worldwide. One of the emerging techniques with tremendous power for lung cancer therapy is magnetic aerosol drug targeting (MADT). The use of a permanent magnet for effective drug delivery in a desired location throughout the lung requires extensive optimization, but it has not been addressed yet. In the present study, the possibility of using a permanent magnet for trapping the particles on a lung tumor is evaluated numerically in the Weibel's model from G0 to G3. The effect of different parameters is considered on the efficiency of particle deposition in a tumor located on a distant position of the lung bronchi and bronchioles. Also, the effective position of the magnetic source, tumor size, and location are the objectives for particle deposition. The results show that a limited particle deposition occurs on the lung branches in passive targeting. However, the incorporation of a permanent magnet next to the tumor enhanced the particle deposition fraction on G2 to up to 49% for the particles of 7 µm diameter. Optimizing the magnet size could also improve the particle deposition fraction by 68%. It was also shown that the utilization of MADT is essential for effective drug delivery to the tumors located on the lower wall of airway branches given the dominance of the air velocity and resultant drag force in this region. The results demonstrated the high competence and necessity of MADT as a noninvasive drug delivery method for lung cancer therapy.

Indexed as

MagnetsModels, BiologicalAerosolsAntineoplastic AgentsDrug Delivery SystemsHumansLungLung NeoplasmsMagnetic Field TherapyMagneticsMicrospheresAerosolsAntineoplastic Agentsaerosol drug targetingbronchial tumorcomputational fluid dynamics (CFD)Lung cancerpermanents magnet

Identifiers

PMID30798633
PMCPMC6394297
OpenAlexW2917687358

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.