Evidence map›Paper›PMID 30798533›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2019

Influenza-Mediated Lung Infection Models.

Charles E McGee, Christopher J Sample, Brita Kilburg-Basnyat, Kristin A Gabor, Michael B Fessler, Kymberly M Gowdy

Open access · greenAbstract read
In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.9field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. STING agonist-containing microparticles improve seasonal influenza vaccine efficacy and durability in ferrets over standard adjuvant.Journal of controlled release : official journal of the Controlled Release Society · 2022
    Article
  4. β-Cyclodextrin-containing polymer treatment of cutaneous lupus and influenza improves outcomes.Molecular therapy : the journal of the American Society of Gene Therapy · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Charles E McGeeDuke Human Vaccine Institute, Duke University Medical Center, Durham, NC, USA.
Christopher J SampleDuke Human Vaccine Institute, Duke University Medical Center, Durham, NC, USA.
Brita Kilburg-BasnyatDepartment of Pharmacology and Toxicology, Brody School of Medicine, East Carolina University, Greenville, NC, USA.
Kristin A GaborImmunity, Inflammation, and Disease Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, USA.
Michael B FesslerImmunity, Inflammation, and Disease Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, USA.
Kymberly M GowdyDepartment of Pharmacology and Toxicology, Brody School of Medicine, East Carolina University, Greenville, NC, USA. Gowdyk14@ecu.edu.
Duke Medical Center · USEast Carolina University · USNational Institute of Environmental Health Sciences · USNational Institutes of Health · US

Funding

Cell Signaling of Host DefenseZIAES102005 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI FESSLER, MICHAEL B · 2009 to 2025
$41.7M
Regional Biocontainment Laboratory (RBL)UC6AI058607 · NIAID · DUKE UNIVERSITY · PI WILLIAMS, R SANDERS · 2003 to 2005
$16.3M
Cell Signaling of Host DefenseZ01ES102005 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI FESSLER, MICHAEL B · 2006 to 2008
$3.3M
Intramural NIH HHS Z01 ES102005Intramural NIH HHS ZIA ES102005NIAID NIH HHS UC6 AI058607NIEHS NIH HHS Z01 ES102005
6 · The paper itself

Abstract

Laboratory rodent influenza infection models have been and continue to be a critical tool for understanding virus-host interactions during infection. The incidence of seasonal influenza infections coupled with the need for novel therapeutics and universal vaccines highlights the need to uncover novel mechanisms of pathogenesis and protection. Mouse models are extremely useful for the evaluation of influenza vaccines and provide an invaluable tool to probe the immune response. This chapter describes the technique of intranasal inoculation of male C57BL/6J mice with an H1N1 strain of influenza (A/Puerto Rico/8/1934) and methods for assessing the optimum dose for infection, viral titers in lung tissue, and severity of disease.

Indexed as

Administration, IntranasalAnimalsDisease Models, AnimalInfluenza VaccinesLungMaleMiceMice, Inbred C57BLOrthomyxoviridae InfectionsVaccinationInfluenza VaccinesBody weight lossFocus-forming unitsH1N1InfluenzaIntranasal inoculationLung damage

Identifiers

PMID30798533
PMCPMC6675590
OpenAlexW2915450609

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.