ArticleAIDS and behavior2019
Engagement in Mental Health Care is Associated with Higher Cumulative Drug Exposure and Adherence to Antiretroviral Therapy.
Article in AIDS and behavior, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
12 citing papers in PubMed, 20 citations in OpenAlex.
- Article
- The Moderating Role of Social Support and HIV Stigma on the Association Between Depression and ART Adherence Among Young Thai Men Who Have Sex with Men.AIDS and behavior · 2023Article
- Mental Health, Self-Care, and Engagement in Care among Black Women Living with HIV.Ethnicity & disease · 2023Article
- The Association Of HIV With Health Care Spending And Use Among Medicare Beneficiaries.Health affairs (Project Hope) · 2022Article
- HIV pre-exposure prophylaxis adherence test using reverse transcription isothermal amplification inhibition assay.Analytical methods : advancing methods and applications · 2022Article
- Article
- Measuring Unmet Needs among Persons Living with HIV at Different Stages of the Care Continuum.AIDS and behavior · 2021Article
- Higher medication complexity in persons with HIV is associated with lower tenofovir diphosphate in dried blood spots.Pharmacotherapy · 2021Article
- Video-Counseling Intervention to Address HIV Care Engagement, Mental Health, and Substance Use Challenges: A Pilot Randomized Clinical Trial for Youth and Young Adults Living with HIV.Telemedicine reports · 2021Article
- Income Inequality Is Associated With Low Cumulative Antiretroviral Adherence in Persons With Human Immunodeficiency Virus.Open forum infectious diseases · 2020Article
- Factors associated with tenofovir diphosphate concentrations in dried blood spots in persons living with HIV.The Journal of antimicrobial chemotherapy · 2020Article
- Mood Disorders and Increased Risk of Noncommunicable Disease in Adults With HIV.Journal of acquired immune deficiency syndromes (1999) · 2020Article
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 1 country.
Funding
Abstract
Mental health (MH) disorders are more prevalent among persons living with HIV compared to the general population, and may contribute to suboptimal adherence to antiretroviral therapy (ART). Tenofovir-diphosphate (TFV-DP), the phosphorylated anabolite of tenofovir (TFV), is a biomarker with a 17-day half-life in red blood cells. TFV-DP can be measured in dried blood spots (DBS) using liquid chromatography/tandem mass spectrometry (LC-MS/MS) to assess adherence and cumulative drug exposure to tenofovir disoproxil fumarate (TDF)-based ART. From a larger clinical cohort (N = 807), TFV-DP concentrations and a paired HIV viral load were available from 521 participants at their enrollment visit. We used multivariable linear regression to evaluate the association between TFV-DP in DBS and engagement in MH care. After adjusting for clinical covariates, participants with MH disorders who were engaged in MH care had 40% higher TFV-DP compared to participants with MH disorders who were not engaged in MH care (p < 0.001), and similar TFV-DP to participants without MH disorders (p = 0.219). Further research is needed to identify the mechanism(s) for these findings, with the goal of optimizing engagement and retention in MH care strategies to improve ART adherence and clinical outcomes in PLWH with MH disorders.
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Registered trials
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