ArticleEuropean child & adolescent psychiatry2019
Abnormal functional network centrality in drug-naïve boys with attention-deficit/hyperactivity disorder.
Article in European child & adolescent psychiatry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 25 citations in OpenAlex.
- Altered intrinsic connectivity in default mode and somatomotor networks in children and adolescents with ADHD: a neuroimaging meta-analysis.European child & adolescent psychiatry · 2026Article
- Advances in neuroimaging studies of thalamic abnormalities in children with attention deficit hyperactivity disorder.Psychoradiology · 2026Review
- Vulnerable brain regions in adolescent attention deficit hyperactivity disorder: An activation likelihood estimation meta-analysis.World journal of psychiatry · 2025Article
- Cognitive Decline in Patients With Trigeminal Neuralgia: A Resting-State fMRI Study.Brain and behavior · 2025Article
- Abnormal stability of dynamic functional architecture in drug-naïve children with attention-deficit/hyperactivity disorder.BMC psychiatry · 2024Article
- Symptom-guided multimodal neuroimage fusion patterns in children with attention-deficit/hyperactivity disorder and its potential "brain structure-function-cognition-behavior" pathological pathways.European child & adolescent psychiatry · 2024Article
- Abnormal intrinsic functional hubs and connectivity in patients with post-stroke depression.Annals of clinical and translational neurology · 2024Article
- Distinct serum GDNF coupling with brain structural and functional changes underlies cognitive status in Parkinson's disease.CNS neuroscience & therapeutics · 2024Article
- Centrality and interhemispheric coordination are related to different clinical/behavioral factors in attention deficit/hyperactivity disorder: a resting-state fMRI study.Brain imaging and behavior · 2022Article
- Shared and Unique Effects of Long-Term Administration of Methylphenidate and Atomoxetine on Degree Centrality in Medication-Naïve Children With Attention-Deficit/Hyperactive Disorder.The international journal of neuropsychopharmacology · 2022Article
- Abnormal hubs in global network as potential neuroimaging marker in generalized anxiety disorder at rest.Frontiers in psychology · 2022Article
- Resting-State fMRI Whole Brain Network Function Plasticity Analysis in Attention Deficit Hyperactivity Disorder.Neural plasticity · 2022Article
- Aberrant Effective Connectivity of the Ventral Putamen in Boys With Attention-Deficit/Hyperactivity Disorder.Psychiatry investigation · 2021Article
- Sex differences in attention deficit hyperactivity symptom severity and functional connectivity of the dorsal striatum in young adults.Neuroimage. Reports · 2021Article
- Changes in sensorimotor regions of the cerebral cortex in congenital amusia: a case-control study.Neural regeneration research · 2021Article
- Abnormal Voxel-Wise Degree Centrality in Patients With Late-Life Depression: A Resting-State Functional Magnetic Resonance Imaging Study.Frontiers in psychiatry · 2019Article
- Abnormal Functional Connectivity in Cognitive Control Network, Default Mode Network, and Visual Attention Network in Internet Addiction: A Resting-State fMRI Study.Frontiers in neurology · 2019Article
- Functional reorganization of brain networks from childhood to adolescence: A multi-level approach.International journal of clinical and health psychology : IJCHPArticle
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
Attention-deficit/hyperactivity disorder (ADHD) is the most commonly diagnosed neurodevelopmental disorder in childhood and is characterized by inattention, impulsivity, and hyperactivity. Observations of distributed functional abnormalities in ADHD suggest aberrant large-scale brain network connectivity. However, few studies have measured the voxel-wise network centrality of boys with ADHD, which captures the functional relationships of a given voxel within the entire connectivity matrix of the brain. Here, to examine the network patterns characterizing children with ADHD, we recruited 47 boys with ADHD and 21 matched control boys who underwent resting-state functional imaging scanning in a 3.0 T MRI unit. We measured voxel-wise network centrality, indexing local functional relationships across the entire brain connectome, termed degree centrality (DC). Then, we chose the brain regions with altered DC as seeds to examine the remote functional connectivity (FC) of brain regions. We found that boys with ADHD exhibited (1) decreased centrality in the left superior temporal gyrus (STG) and increased centrality in the left superior occipital lobe (SOL) and right inferior parietal lobe (IPL); (2) decreased FC between the STG and the putamen and thalamus, which belong to the cognitive cortico-striatal-thalamic-cortical (CSTC) loop, and increased FC between the STG and medial/superior frontal gyrus within the affective CSTC loop; and (3) decreased connectivity between the SOL and cuneus within the dorsal attention network. Our results demonstrated that patients with ADHD show a connectivity-based pathophysiological process in the cognitive and affective CSTC loops and attention network.
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