ReviewJournal of critical care2019
Severe acute respiratory distress syndrome (ARDS) induced by human adenovirus B21: Report on 2 cases and literature review.
Review in Journal of critical care, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- Pooled it
- Genomic Characterization of Human Adenovirus Type 21 Strains - 7 PLADs, China, 2023-2024.China CDC weekly · 2025Article
- Treatment of Severe Adenovirus Infection With HAdV-B21 in a Young Obese Male With Normal Immunity.Clinical case reports · 2025Article
- Article
- Epidemiological characteristics of adenovirus in children in Yancheng, China, 2023-2024.Frontiers in cellular and infection microbiology · 2025Article
- Severe adenovirus pneumonia complicated by acute respiratory distress syndrome in immunocompetent patients: a case report and literature review.Frontiers in medicine · 2025Article
- Adenovirus infections: new insights for the clinical laboratory.Journal of clinical microbiology · 2024Review
- Genotypes and Phylogenetic Analysis of Human Adenovirus in Hospitalized Pneumonia and Influenza-Like Illness Patients in Jiangsu Province, China (2013-2021).Infection and drug resistance · 2024Article
- Review
- [Silencing CD46 and DSG2 in host A549 cells inhibits entry of human adenovirus type 3 and type 7 and reduces interleukin-8 release].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2022Article
- Construction and Verification of a Predictive Model for Risk Factors in Children With Severe Adenoviral Pneumonia.Frontiers in pediatrics · 2022Article
- Human Adenovirus Subtype 21a Isolates From Children With Severe Lower Respiratory Illness in China.Frontiers in microbiology · 2022Article
- Usefulness of metagenomic next-generation sequencing in adenovirus 7-induced acute respiratory distress syndrome: A case report.World journal of clinical cases · 2021Article
- Diversity of enteric and non-enteric human adenovirus strains in Brazil, 2006-2011.Archives of virology · 2021Article
- Acute Respiratory Distress Syndrome Caused by Human Adenovirus in Adults: A Prospective Observational Study in Guangdong, China.Frontiers in medicine · 2021Article
- Cytokine/Chemokine Expression Is Closely Associated Disease Severity of Human Adenovirus Infections in Immunocompetent Adults and Predicts Disease Progression.Frontiers in immunology · 2021Article
- Update in Viral Infections in the Intensive Care Unit.Frontiers in medicine · 2021Review
- Evaluation of Risk Factors for Exacerbations in Children with Adenoviral Pneumonia.BioMed research international · 2020Article
- First Identification of Human Adenovirus Subtype 21a in China With MinION and Illumina Sequencers.Frontiers in genetics · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Severe pneumonia and ARDS caused by human adenovirus B21 infections (HAdV-B21) is a rare, but a devastating disease with rapid progression to multiorgan failure and death. However, only a few cases were reported so far. Infections appear associated with increased disease severity and higher mortality in infected critically ill patients. Possible factors contributing to infection are underlying psychiatric disease resulting in institutionalization of respective patients, and polytoxicomania. Controlled data on the therapy of severe adenovirus infections are lacking and remains experimental. In conclusion, data on HAdV-B21 infections causing severe pneumonia or ARDS are scarce. Controlled clinical trials on the therapy of adenovirus pneumonia are non existent and thus there is no established therapy so far. ICU physicians should be aware of this potentially devastating disease and further studies are needed.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.