ReviewFrontiers in neuroendocrinology2019
Neuroendocrinology of reproduction: Is gonadotropin-releasing hormone (GnRH) dispensable?
Review in Frontiers in neuroendocrinology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 60 citations in OpenAlex.
- Strategies to reduce cholesterol content in poultry eggs: an overview.Tropical animal health and production · 2026Review
- Differential hypothalamic expression of Musashi protein 2 in Mongolian sheep with single and double ovulation.Frontiers in veterinary science · 2026Article
- An optimized method for directed differentiation of hypothalamic neural stem cells in a 3D culture system.Scientific reports · 2025Article
- GnRH Peptide Antagonist: Comparative Analysis of Chemistry and Formulation with Implications for Clinical Safety and Efficacy.Pharmaceuticals (Basel, Switzerland) · 2024Review
- The satiety hormone cholecystokinin gates reproduction in fish by controlling gonadotropin secretion.eLife · 2024Article
- Expression of GnRH, Kisspeptin, and Their Specific Receptors in the Ovary and Uterus in Deslorelin-Treated Late-Prepubertal Bitches.Veterinary sciences · 2024Article
- Structure-guided design and evaluation of CRM197-scaffolded vaccine targeting GnRH for animal immunocastration.Applied microbiology and biotechnology · 2024Article
- Assessment of the efficacy of a gonadotropin releasing factor (GnRF) analog to suppress ovarian function in gilts under pre-clinical and clinical conditions.Porcine health management · 2024Article
- Identification of the FSH-RH as the other gonadotropin-releasing hormone.Nature communications · 2024Article
- Characterizing the SREB G protein-coupled receptor family in fish: Brain gene expression and genomic differences in upstream transcription factor binding sites.Comparative biochemistry and physiology. Part A, Molecular & integrative physiology · 2023Article
- hnRNP E1 Regulates HPV16 Oncogene Expression and Inhibits Cervical Cancerization.Frontiers in oncology · 2022Article
- Tachykinins, new players in the control of reproduction and food intake: A comparative review in mammals and teleosts.Frontiers in endocrinology · 2022Review
- Overview and New Insights Into the Diversity, Evolution, Role, and Regulation of Kisspeptins and Their Receptors in Teleost Fish.Frontiers in endocrinology · 2022Review
- Article
- Exogenous cortisol and red light irradiation affect reproductive parameters in the goldfish Carassius auratus.Fish physiology and biochemistry · 2021Article
- Characterization of the G protein-coupled receptor family SREB across fish evolution.Scientific reports · 2021Article
- Reproductive Regulation of PrRPs in Teleost: The Link Between Feeding and Reproduction.Frontiers in endocrinology · 2021Article
- Fish reproductive biology - Reflecting on five decades of fundamental and translational research.General and comparative endocrinology · 2021Review
- Evolutionarily conserved peptides coordinate lunar phase and metabolism.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
Gonadotropin releasing hormone (GnRH) is a highly conserved neuroendocrine decapeptide that is essential for the onset of puberty and the maintenance of the reproductive state. First identified in mammals, the GnRH signaling pathway is found in all classes of vertebrates; homologues of GnRH have also been identified in invertebrates. In addition to its role as a hypothalamic releasing hormone, GnRH has multiple functions including modulating neural activity within specific regions of the brain. These various functions are mediated by multiple isoforms, which are expressed at diverse locations within the central nervous system. Here we discuss the GnRH signaling pathways in light of new reports that reveal that some vertebrate genomes lack GnRH1. Not only do other isoforms of GnRH not compensate for this gene loss, but elements upstream of GnRH1, including kisspeptins, appear to also be dispensable. We discuss routes that may compensate for the loss of the GnRH1 pathway.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.