ArticleVaccine2019
Race-related differences in functional antibody response to pneumococcal vaccination in HIV-infected individuals.
Article in Vaccine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03039491 (Immune Response to Pneumococcal Vaccination in Aging HIV Positive Individuals), which is not on this map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Immune Response to Pneumococcal Vaccination in Aging HIV Positive Individuals
Who cites it
5 citing papers in PubMed, 13 citations in OpenAlex.
- Autonomic neuropathy is associated with an increase in type-1 cytokines in people living with HIV.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2025Article
- Autonomic Neuropathy Is Associated with An Increase in Type-1 Cytokines in People Living With HIV.bioRxiv : the preprint server for biology · 2025Article
- Article
- Longitudinal assessment of symptoms and risk of SARS-CoV-2 infection in healthcare workers across 5 hospitals to understand ethnic differences in infection risk.EClinicalMedicine · 2021Article
- Will We Have a Cohort of Healthcare Workers Full Vaccinated against Measles, Mumps, and Rubella?Vaccines · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundBoth HIV positivity and African American (AA) ethnicity are associated with increased incidence of invasive pneumococcal disease (IPD). Poor immune response to pneumococcal polysaccharide-based vaccines may contribute to the race related increased frequency of IPD in African American HIV positive individuals.
methodsCaucasian and AA HIV-infected (HIV+) individuals 40-65 years old with CD4
resultsThere were no significant differences in pre-immunization inflammatory markers or post-vaccination IgG and IgM concentrations between Caucasian and African American participants. However, we found significantly lower opsonophagocytic activity in response to serotypes 14 and 19A in the AA group compared to the Caucasian group. There was no association between inflammatory markers and immune response to vaccination, however we found extensive biomodal variation in gene expression levels in single IgM+ memory B cells. Differentially expressed genes may be related to differences in the immune response between ethnic groups.
conclusionsDistinct racial differences were found in the functional immune response following either PPV and/or PCV/PPV immunization in HIV-positive adults, although these differences were serotype dependent. Decreased ability to respond to vaccination may in part explain racial disparities in pneumococcal disease epidemiology. ClinicalTrials.gov ID: NCT03039491.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.