ReviewCurrent topics in developmental biology2019
Fluid forces shape the embryonic heart: Insights from zebrafish.
Review in Current topics in developmental biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed, 48 citations in OpenAlex.
- Coordination of cardiogenesis in vivo and in vitro.Nature reviews. Molecular cell biology · 2026Review
- Mechanically activated snai1b coordinates the initiation of myocardial delamination for trabeculation.Nature communications · 2025Article
- Contraction-induced endocardialeLife · 2025Article
- Genetically encoded tension heterogeneity sculpts cardiac trabeculation.Science advances · 2025Article
- Article
- Optical Elastography for Micropressure Characterization of Zebrafish Embryonic Cardiac Development.Annals of biomedical engineering · 2024Article
- Hemodynamics During Development and Postnatal Life.Advances in experimental medicine and biology · 2024Review
- Biological Responses of Pacific Herring Embryos to Crude Oil Are Quantifiable at Exposure Levels Below Conventional Limits of Quantitation for PAHs in Water and Tissues.Environmental science & technology · 2023Article
- Biallelic variants in FLII cause pediatric cardiomyopathy by disrupting cardiomyocyte cell adhesion and myofibril organization.JCI insight · 2023Article
- Article
- Recent advances in quantifying the mechanobiology of cardiac development via computational modeling.Current opinion in biomedical engineering · 2023Article
- TheFrontiers in physiology · 2023Article
- Following the Beat: Imaging the Valveless Pumping Function in the Early Embryonic Heart.Journal of cardiovascular development and disease · 2022Review
- A Combined HumanFrontiers in pharmacology · 2022Article
- Cardiac forces regulate zebrafish heart valve delamination by modulating Nfat signaling.PLoS biology · 2022Article
- Fluid mechanics of the left atrial ligation chick embryonic model of hypoplastic left heart syndrome.Biomechanics and modeling in mechanobiology · 2021Article
- The Zebrafish Cardiac Endothelial Cell-Roles in Development and Regeneration.Journal of cardiovascular development and disease · 2021Review
- Computational Modeling of Blood Flow Hemodynamics for Biomechanical Investigation of Cardiac Development and Disease.Journal of cardiovascular development and disease · 2021Review
- Mechanoregulation of PDZ Proteins, An Emerging Function.Methods in molecular biology (Clifton, N.J.) · 2021Review
- Cardiac Morphogenesis: Specification of the Four-Chambered Heart.Cold Spring Harbor perspectives in biology · 2020Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Heart formation involves a complex series of tissue rearrangements, during which regions of the developing organ expand, bend, converge, and protrude in order to create the specific shapes of important cardiac components. Much of this morphogenesis takes place while cardiac function is underway, with blood flowing through the rapidly contracting chambers. Fluid forces are therefore likely to influence the regulation of cardiac morphogenesis, but it is not yet clear how these biomechanical cues direct specific cellular behaviors. In recent years, the optical accessibility and genetic amenability of zebrafish embryos have facilitated unique opportunities to integrate the analysis of flow parameters with the molecular and cellular dynamics underlying cardiogenesis. Consequently, we are making progress toward a comprehensive view of the biomechanical regulation of cardiac chamber emergence, atrioventricular canal differentiation, and ventricular trabeculation. In this review, we highlight a series of studies in zebrafish that have provided new insight into how cardiac function can shape cardiac morphology, with a particular focus on how hemodynamics can impact cardiac cell behavior. Over the long-term, this knowledge will undoubtedly guide our consideration of the potential causes of congenital heart disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.