ArticleLife sciences in space research2019
Effects of low-dose oxygen ions and protons on cardiac function and structure in male C57BL/6J mice.
Article in Life sciences in space research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Biological effects of high-LET irradiation on the circulatory system.International journal of radiation biology · 2025Pooled it
- Cardiovascular risks and hazards associated with deep space exploration.Communications medicine · 2026Review
- Sex-specific effects on the heart from combined exposure to simulated galactic cosmic radiation and hindlimb unloading.Life sciences in space research · 2025Article
- Consequences of ionizing radiation exposure to the cardiovascular system.Nature reviews. Cardiology · 2024Review
- Space Travel: The Radiation and Microgravity Effects on the Cardiovascular System.International journal of molecular sciences · 2024Review
- Modeling the Effects of Protracted Cosmic Radiation in a Human Organ-on-Chip Platform.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Cardiovascular adaptations and pathological changes induced by spaceflight: from cellular mechanisms to organ-level impacts.Military Medical Research · 2024Review
- Simulated Microgravity Alters Gene Regulation Linked to Immunity and Cardiovascular Disease.Genes · 2024Article
- Proteomic and phosphoproteomic characterization of cardiovascular tissues after long term exposure to simulated space radiation.Frontiers in physiology · 2024Article
- Effects of proton and oxygen ion irradiation on cardiovascular function and structure in a rabbit model.Life sciences in space research · 2023Article
- Effects of Simulated 5-Ion Galactic Cosmic Radiation on Function and Structure of the Mouse Heart.Life (Basel, Switzerland) · 2023Article
- Article
- Lifetime evaluation of left ventricular structure and function in male ApoE null mice after gamma and space-type radiation exposure.Frontiers in physiology · 2023Article
- Is space flight arrhythmogenic?Frontiers in physiology · 2023Article
- Late onset cardiovascular dysfunction in adult mice resulting from galactic cosmic ray exposure.iScience · 2022Article
- Leveraging Spaceflight to Advance Cardiovascular Research on Earth.Circulation research · 2022Review
- Effects of low-dose oxygen ions on cardiac function and structure in female C57BL/6J mice.Life sciences in space research · 2022Article
- Mitigation of late cardiovascular effects of oxygen ion radiation by γ-tocotrienol in a mouse model.Life sciences in space research · 2021Article
- Spaceflight Modulates the Expression of Key Oxidative Stress and Cell Cycle Related Genes in Heart.International journal of molecular sciences · 2021Article
- Late Health Effects of Partial Body Irradiation Injury in a Minipig Model Are Associated with Changes in Systemic and Cardiac IGF-1 Signaling.International journal of molecular sciences · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 3 institutions in 1 country.
Funding
Abstract
purposeAstronauts traveling beyond low-Earth orbit will be exposed to high linear-energy transfer charged particles. Because there is concern about the adverse effects of space radiation on the cardiovascular system, this study assessed cardiac function and structure and immune cell infiltration in a mouse model of charged-particle irradiation. MATERIALS AND
methodsMale C57BL/6 J mice were exposed to oxygen ions (
resultsEjection fraction and fractional shortening decreased at 3 and 7 months after
conclusionsLow-dose, high-energy charged-particle irradiation caused mild changes in cardiac function and tissue remodeling in the mouse.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.