ArticleArchives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists2019
Visual Object Perception in Premanifest and Early Manifest Huntington's Disease.
Article in Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Early Language Impairment as an Integral Part of the Cognitive Phenotype in Huntington's Disease.Annals of clinical and translational neurology · 2025Article
- Cognitive phenotype and neurodegeneration associated with Tau in Huntington's disease.Annals of clinical and translational neurology · 2024Article
- Metacognitive insight into cognitive performance in Huntington's disease gene carriers.BMJ neurology open · 2022Article
- Structural brain correlates of dementia in Huntington's disease.NeuroImage. Clinical · 2020Article
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Authors and funding
5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
objectiveIn Huntington's disease (HD), a hereditary neurodegenerative disorder, cognitive impairment in early disease stages mainly involves executive dysfunction. However, visual cognitive deficits have additionally been reported and are of clinical relevance given their influence on daily life and overall cognitive performance. This study aimed to assess visual perceptual skills in HD gene carriers.
methodsSubtasks of the Visual Object and Space Perception battery and Groningen Intelligence Test were administered in 62 participants (18 healthy controls, 22 participants with a genetic confirmation of HD without symptoms, i.e., premanifest HD, and 22 participants with a genetic confirmation of HD with symptoms, i.e., manifest HD). Group differences in task performance were measured using analysis of covariance with and without correction for age. Receiver Operating Characteristics (ROC) analysis was performed to examine which task best discriminated between groups and cut-off scores were provided.
resultsManifest HD performed significantly worse compared to both controls and premanifest HD on all visual perceptional tasks. Premanifest HD did not differ in task performance from controls. Besides the Shape Detection, all tasks were robust in discriminating between groups. The Animal Silhouettes test was most accurate in discriminating manifest HD from premanifest HD (AUC = 0.90, SE = 0.048, p < .001).
conclusionVisual perceptual deficits are present in early manifest HD, especially an impaired recognition of animals and objects from sketched silhouettes, and not in premanifest HD. This suggests that decline in visual processing only occurs in clinical disease stages. The visual cognitive battery, especially the Silhouettes tasks used in this study is sensitive in discriminating manifest HD from premanifest HD and controls.
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