Evidence map›Paper›PMID 30796745›Full record

ArticleJournal of neuro-oncology2019

Longer genotypically-estimated leukocyte telomere length is associated with increased meningioma risk.

Ivo S Muskens, Helen M Hansen, Ivan V Smirnov, Annette M Molinaro, Melissa L Bondy, Joellen M Schildkraut, Margaret Wrensch, Joseph L Wiemels, Elizabeth B Claus

Open access · greenAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neuro-oncology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Epidemiology of Brain and Other CNS Tumors.Current neurology and neuroscience reports · 2021
    Review
  7. Article
  8. Article
  9. Article
  10. An Overview of Managements in Meningiomas.Frontiers in oncology · 2020
    Review
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 1 country.

Ivo S MuskensDepartment of Neurosurgery, Brigham and Woman's Hospital, Boston, MA, USA.
Helen M HansenDepartment of Neurological Surgery, School of Medicine, University of California, San Francisco, San Francisco, CA, USA.
Ivan V SmirnovDepartment of Neurological Surgery, School of Medicine, University of California, San Francisco, San Francisco, CA, USA.
Annette M MolinaroDepartment of Neurological Surgery, School of Medicine, University of California, San Francisco, San Francisco, CA, USA.
Melissa L BondySection of Epidemiology and Popular Sciences, Department of Medicine, Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX, USA.
Joellen M SchildkrautDepartment of Public Health Sciences, University of Virginia School of Medicine, Charlottesville, VA, USA.
Margaret WrenschDepartment of Neurological Surgery, School of Medicine, University of California, San Francisco, San Francisco, CA, USA.
Joseph L WiemelsCenter for Genetic Epidemiology, Department of Preventative Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Elizabeth B ClausDepartment of Neurosurgery, Brigham and Woman's Hospital, Boston, MA, USA. elizabeth.claus@yale.edu.
University of California, San Francisco · USNeurological Surgery · USBaylor College of Medicine · USUniversity of Virginia · USWoman's Hospital · USYale University · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Tissue CoreP50CA097257 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Joseph F Costello · 2002 to 2026
$57.4M
GENETIC EPIDEMIOLOGY OF MALIGNANT GLIOMAR01CA052689 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WIENCKE, JOHN K., WRENSCH, MARGARET R. · 1991 to 2015
$20.5M
Training in Molecular& Genetic Epidemiology of CancerR25CA112355 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WITTE, JOHN S. · 2005 to 2018
$6.5M
The Meningioma Consortium: Genome-Wide Association StudyR01CA151933 · NCI · YALE UNIVERSITY · PI CLAUS, ELIZABETH B. · 2010 to 2013
$3.7M
Meningioma: Risk Factors and Quality of LifeR01CA109468 · NCI · YALE UNIVERSITY · PI CLAUS, ELIZABETH B. · 2006 to 2010
$3.3M
Meningioma: Risk Factors and Quality of LifeR01CA109745 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WIEMELS, JOSEPH LEO · 2006 to 2010
$1.9M
Training in the Molecular & Genetic Epidemiology of CancerT32CA112355 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHENG, IONA C, ZIV, ELAD · 2020 to 2024
$1.8M
Meningioma: Risk Factors and Quality of LifeR01CA109475 · NCI · DUKE UNIVERSITY · PI ILYASOVA, DORA · 2006 to 2010
$1.4M
Meningioma: Risk Factors and Quality of LifeR01CA109473 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI BONDY, MELISSA L. · 2006 to 2010
$1.1M
Meningioma: Risk Factors and Quality of LifeR01CA109461 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI CLAUS, ELIZABETH B. · 2006 to 2010
$1.1M
Brain Science Foundation Not applicableMeningioma Mommas Not applicableNational Institutes of Health (US) CA109475NCATS NIH HHS UL1 TR001863NCI NIH HHS P50 CA097257NCI NIH HHS R01 CA052689NCI NIH HHS R01 CA109461NCI NIH HHS R01 CA109468NCI NIH HHS R01 CA109473NCI NIH HHS R01 CA109475NCI NIH HHS R01 CA109745NCI NIH HHS R01 CA151933NCI NIH HHS R25 CA112355NCI NIH HHS T32 CA112355NIH HHS CA097257NIH HHS CA109461NIH HHS CA109468NIH HHS CA109473NIH HHS CA109745NIH HHS CA112355NIH HHS CA52689University of California, San Francisco Not applicable
6 · The paper itself

Abstract

purposeTelomere length-associated SNPs have been associated with incidence and survival rates for malignant brain tumors such as glioma. Here, we study the influence of genetically determined lymphocyte telomere length (LTL) by comparing telomerase associated SNPs between the most common non-malignant brain tumor, i.e. meningioma, and healthy controls. METHODS/PATIENTS: One thousand fifty-three (1053) surgically treated meningioma patients and 4437 controls of Western European ancestry were included. Germline DNA was genotyped for 8 SNPs previously significantly associated with LTL. Genotypically-estimated LTL was then calculated by summing each SNP's genotypically-specified telomere length increase in base pairs (bp) for each person. Odds ratios for genotypically-estimated LTL in meningioma cases and controls were evaluated using logistic regression with the first two ancestral principal components and sex as covariates.

resultsThree out of the eight evaluated LTL SNPs were significantly associated with increased meningioma risk (rs10936599: OR 1.14, 95% CI 1.01-1.28, rs2736100: OR 1.13, 95% CI 1.03-1.25, rs9420907: OR 1.22, 95% CI 1.07-1.39). Only rs9420907 remained significant after correction for multiple testing. Average genotypically-estimated LTL was significantly longer for those with meningioma compared to controls [mean cases: 560.2 bp (standard error (SE): 4.05 bp), mean controls: 541.5 bp (SE: 2.02 bp), logistic regression p value = 2.13 × 10

conclusionIncreased genotypically-estimated LTL was significantly associated with increased meningioma risk. A role for telomere length in the pathophysiology of meningioma is novel, and could lead to new insights on the etiology of meningioma.

Indexed as

Polymorphism, Single NucleotideTelomere HomeostasisCase-Control StudiesFemaleFollow-Up StudiesGenotypeHumansLeukocytesMaleMeningeal NeoplasmsMeningiomaPrognosisRisk FactorsLeukocyte telomere lengthMendelian randomizationMeningiomaRisk

Identifiers

PMID30796745
PMCPMC6482066
OpenAlexW2916400861

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.