Evidence map›Paper›PMID 30796709›Full record

Trial reportMolecular imaging and biology2019

Confirmation of Specific Binding of the 18-kDa Translocator Protein (TSPO) Radioligand [

Sujata Sridharan, Joel Raffel, Ashwini Nandoskar, Chris Record, David J Brooks, David Owen, David Sharp, Paolo A Muraro, Roger Gunn, Richard Nicholas

Open access · hybridAbstract readClinical Trial
PubMed Publisher
In one paragraph

Trial report in Molecular imaging and biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. [Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024
    Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Have (R)-[European journal of nuclear medicine and molecular imaging · 2021
    Article
  9. Article
  10. Impact of TSPO Receptor Polymorphism on [Life (Basel, Switzerland) · 2021
    Article
  11. Membrane-embedded TSPO: an NMR view.European biophysics journal : EBJ · 2021
    Article
  12. Article
  13. Review
  14. Reliable quantification ofEuropean journal of nuclear medicine and molecular imaging · 2020
    Article
  15. 18F-GE180, a radioligand for the TSPO protein: not ready for clinical trials in multiple sclerosis.European journal of nuclear medicine and molecular imaging · 2020
    Article
  16. In response to: Anatomy ofEuropean journal of nuclear medicine and molecular imaging · 2020
    Article
  17. Anatomy ofEuropean journal of nuclear medicine and molecular imaging · 2020
    Article
  18. TSPO PET, tumour grading and molecular genetics in histologically verified glioma: a correlativeEuropean journal of nuclear medicine and molecular imaging · 2020
    Article
  19. Concentration, distribution, and influence of aging on the 18 kDa translocator protein in human brain: Implications for brain imaging studies.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2020
    Article
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Sujata SridharanDivision of Brain Sciences, Faculty of Medicine, Imperial College London, Hammersmith Hospital Campus, Burlington Danes Building, Du Cane Road, London, W12 0NN, UK. s.sridharan@imperial.ac.uk.ORCID 0000-0002-3194-6662
Joel RaffelDivision of Brain Sciences, Faculty of Medicine, Imperial College London, Hammersmith Hospital Campus, Burlington Danes Building, Du Cane Road, London, W12 0NN, UK.
Ashwini NandoskarDivision of Brain Sciences, Faculty of Medicine, Imperial College London, Hammersmith Hospital Campus, Burlington Danes Building, Du Cane Road, London, W12 0NN, UK.
Chris RecordDivision of Brain Sciences, Faculty of Medicine, Imperial College London, Hammersmith Hospital Campus, Burlington Danes Building, Du Cane Road, London, W12 0NN, UK.
David J BrooksDivision of Brain Sciences, Faculty of Medicine, Imperial College London, Hammersmith Hospital Campus, Burlington Danes Building, Du Cane Road, London, W12 0NN, UK.
David OwenDivision of Brain Sciences, Faculty of Medicine, Imperial College London, Hammersmith Hospital Campus, Burlington Danes Building, Du Cane Road, London, W12 0NN, UK.
David SharpDivision of Brain Sciences, Faculty of Medicine, Imperial College London, Hammersmith Hospital Campus, Burlington Danes Building, Du Cane Road, London, W12 0NN, UK.
Paolo A MuraroDivision of Brain Sciences, Faculty of Medicine, Imperial College London, Hammersmith Hospital Campus, Burlington Danes Building, Du Cane Road, London, W12 0NN, UK.
Roger GunnInvicro Ltd., London, UK.
Richard NicholasDivision of Brain Sciences, Faculty of Medicine, Imperial College London, Hammersmith Hospital Campus, Burlington Danes Building, Du Cane Road, London, W12 0NN, UK.
Hammersmith Hospital · GBAarhus University · DKInvicro (United Kingdom) · GB

Funding

Department of Health NIHR-RP-011-048Medical Research Council MR/N008219/1
6 · The paper itself

Abstract

purposeMeasurements of non-displaceable binding (V PROCEDURES: Twelve people with MS underwent baseline MRI and 90-min dynamic [

resultsWhole brain V

conclusionsAlthough V

Indexed as

AdultCarbazolesFemaleGray MatterHumansLinear ModelsMaleMiddle AgedMultiple SclerosisProtein BindingPurinesRadiopharmaceuticalsReceptors, GABAReproducibility of ResultsWhite MatterCarbazolesGE-180N-benzyl-N-ethyl-2-(7,8-dihydro-7-methyl-8-oxo-2-phenyl-9H-purin-9-yl)acetamidePurinesRadiopharmaceuticalsReceptors, GABATSPO protein, human[11C]PBR28[18F]GE-180Multiple sclerosisOccupancy plotPETPolymorphism plotXBD173

Identifiers

PMID30796709
OpenAlexW2917210717

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.