ArticleFolia microbiologica2019
Purification and characterization of pediocin from probiotic Pediococcus pentosaceus GS4, MTCC 12683.
Article in Folia microbiologica, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 45 citations in OpenAlex.
- Probiotics: multifunctional microorganisms for human health and biotechnological applications.Frontiers in microbiology · 2026Review
- Draft whole-genome sequence ofMicrobiology resource announcements · 2025Article
- Lactic Acid Bacteria Bacteriocins: Safe and Effective Antimicrobial Agents.International journal of molecular sciences · 2025Review
- Action and immunomodulatory mechanisms, formulations, and safety concerns of probiotics.Bioscience of microbiota, food and health · 2025Review
- Influence of different culture media on the antimicrobial activity of Pediococcus pentosaceus ST65ACC against Listeria monocytogenes.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2024Article
- Whole-genome analysis suggesting probiotic potential and safety properties ofFrontiers in microbiology · 2024Article
- Effects of dietary supplementation ofJournal of animal science and technology · 2023Article
- Use of two autochthonous bacteriocinogenic strains as starter cultures in the production ofCurrent research in food science · 2023Article
- Characterization of novel bacteriocin PB2 and comprehensive detection of the pediocin gene ped-A1 from Pediococcus pentosaceus PB2 strain isolated from a sorghum-based fermented beverage in Nigeria.Biotechnology reports (Amsterdam, Netherlands) · 2022Article
- Beneficial features of pediococcus: from starter cultures and inhibitory activities to probiotic benefits.World journal of microbiology & biotechnology · 2022Review
- Pan-genomic and comparative analysis ofComputational and structural biotechnology journal · 2022Article
- A synthetic probiotic engineered for colorectal cancer therapy modulates gut microbiota.Microbiome · 2021Article
- Pediococcus pentosaceus, a future additive or probiotic candidate.Microbial cell factories · 2021Review
- Antibacterial Activity of Pediocin and Pediocin-Producing Bacteria AgainstFrontiers in microbiology · 2021Review
- Review
- Article
- Controlling foodborne pathogens with natural antimicrobials by biological control and antivirulence strategies.Heliyon · 2020Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pediococcus pentosaceus GS4 (MTCC 12683), a probiotic lactic acid bacterium (LAB), was found to produce bacteriocin in spent culture. Antibacterial and antagonistic potential of this bacteriocin against reference strains of Staphylococcus aureus (ATCC 25923), Escherichia coli (ATCC 25922), Pseudomonas aeruginosa (ATCC 25619), and Listeria monocytogenes (ATCC 15313) was proven by double-layer and well diffusion methods wherein nisin and ampicillin were used as positive controls. Bacteriocin in supernatant was purified and analyzed by SDS-PAGE, RP-HPLC, and circular dichroism (CD). The physico-chemical properties of purified bacteriocin were characterized being treated at different temperatures (30 to 110 °C), pH (3.0 to 12.0), with different enzymes (α-amylase, pepsin, and lysozyme), and organic solvents (hexane, ethanol, methanol, and acetone) respectively. The molar mass of bacteriocin (named pediocin GS4) was determined as 9.57 kDa. The single peak appears at the retention time of 2.403 with area amounting to 25.02% with nisin as positive control in RP-HPLC. CD analysis reveals that the compound appears to have the helix ratio of 40.2% with no beta sheet. The antibacterial activity of pediocin GS4 was optimum at 50 °C and at pH 5.0 and 7.0. The pediocin GS4 was not denatured by the treatment of amylase and lysozyme but was not active in the presence of organic solvents. This novel bacteriocin thus m ay be useful in food and health care industry.
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