ArticleJournal of natural medicines2019
Rhamnan sulfate extracted from Monostroma nitidum attenuates blood coagulation and inflammation of vascular endothelial cells.
Article in Journal of natural medicines, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 30 citations in OpenAlex.
- Rhamnan sulphate from green algae Monostroma nitidum improves constipation with gut microbiome alteration in double-blind placebo-controlled trial.Scientific reports · 2021Trial
- Sepsis-induced endothelial glycocalyx disruption and remodeling: an ultrastructural study in mice.Intensive care medicine experimental · 2026Article
- Orally Administered Rhamnan Sulfate fromMarine drugs · 2026Article
- Rhamnan Sulfate from the SeaweedMarine drugs · 2025Article
- Sustainable and biocompatible hybrid materials-based sulfated polysaccharides for biomedical applications: a review.RSC advances · 2025Review
- Lipid- and glucose-lowering effects of Rhamnan sulphate fromFood science & nutrition · 2024Article
- Oral Administration of Rhamnan Sulfate fromCells · 2023Article
- Marine Biological Macromolecules and Chemically Modified Macromolecules; Potential Anticoagulants.Marine drugs · 2022Review
- Biological activity of a vascular endothelial cell-hydroxyapatite orbital implant complex: An experimental study.Experimental and therapeutic medicine · 2022Article
- Anti-Inflammatory Activity of Orally AdministeredMarine drugs · 2022Article
- Effect ofFrontiers in microbiology · 2022Article
- Article
- The Glycocalyx and Its Role in Vascular Physiology and Vascular Related Diseases.Cardiovascular engineering and technology · 2021Review
- Anti-Influenza A Virus Activity of Rhamnan Sulfate from Green AlgaeMarine drugs · 2020Article
- Biological Activities of Rhamnan Sulfate Extract from the Green AlgaeMarine drugs · 2020Review
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 1 country.
Funding
Abstract
Rhamnan sulfate (RS) is a polysaccharide with a rhamnose backbone isolated from Monostroma nitidum. Like heparin, it exerts anticoagulant activity in the presence of antithrombin. Endothelial cells facilitate the crosstalk between blood coagulation and vascular inflammation. In this study, we compared the effect of RS with that of heparin on blood coagulation and vascular endothelial cells in the presence or absence of inflammatory factors, using human umbilical vein endothelial cells. We found that RS significantly enhances inhibition of thrombin and factor Xa in the presence of antithrombin as well as heparin, and that RS inhibits tissue factor expression and von Willebrand factor release from the endothelial cells treated with or without lipopolysaccharide, tumor necrosis factor-α, or thrombin. Heparin did not show any effects on endothelial cell inflammation. Our findings suggest that RS, like heparin, is an antithrombin-dependent anticoagulant and, unlike heparin, is a potent anti-inflammatory agent acting on vascular endothelial cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.