Evidence map›Paper›PMID 30796581›Full record

ArticleEuropean journal of epidemiology2019

Expanding disease and undermining the ethos of medicine.

Bjørn Hofmann

Abstract read
PubMed Publisher
In one paragraph

Article in European journal of epidemiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Underdiagnosis of Health: A Key Driver of Overdiagnosis of Disease.Journal of evaluation in clinical practice · 2026
    Article
  2. Article
  3. Addressing the overuse-underuse paradox in healthcare.Medicine, health care, and philosophy · 2025
    Article
  4. Bearing the Burdens of Medical Uncertainty.Journal of evaluation in clinical practice · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. The role of philosophy and ethics at the edges of medicine.Philosophy, ethics, and humanities in medicine : PEHM · 2021
    Article
  10. Article
  11. Article
  12. How to Draw the Line Between Health and Disease? Start with Suffering.Health care analysis : HCA : journal of health philosophy and policy · 2021
    Article
  13. Review
  14. Nosology expansion: not always for health's sake.European journal of epidemiology · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Bjørn HofmannDepartment for the Health Sciences, Norwegian University of Science and Technology (NTNU), Gjovik, Norway. b.m.hofmann@medisin.uio.no.ORCID http://orcid.org/0000-0001-6709-4265

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The expansion of the concept of disease poses problems for epidemiology. Certainly, new diseases are discovered and more people are treated earlier and better. However, the historically unprecedented expansion is criticised for going too far. Overdiagnosis, overtreatment, and medicalization are some of the challenges heatedly debated in medicine, media, and in health policy making. How are we to analyse and handle the vast expansion of disease? Where can we draw the line between warranted and unwarranted expansion? To address this issue, which has wide implications for epidemiology, we need to understand how disease is expanded. This article identifies six ways that our conception of disease is expanded: by increased knowledge (epistemic), making more phenomena count as disease (ontological), doing more (pragmatic), defining more (conceptual), and by encompassing the bad (ethic) and the ugly (aesthetic). Expanding the subject matter of medicine extends its realm and power, but also its responsibility. It makes medicine accountable for ever more of human potential dis-eases. At the same time it blurs the borders and undermines the demarcation of medicine. Six specific advices can guide our action clarifying the subject matter of medicine in general and epidemiology in particular. To avoid unlimited responsibility and to keep medicine on par with its end, we need to direct the expansion of disease to what effectively identifies or reduces human suffering. Otherwise we will deplete medicine and undermine the greatest asset in health care: trust.

Indexed as

DiseaseEthics, MedicalKnowledgeMedicalizationMedical OveruseBiological OntologiesDiagnostic ErrorsHumansRisk AssessmentUnnecessary ProceduresAestheticsConcept of diseaseDiagnosticsEpistemologyEthicsExpansionOntologyOverdiagnosisPhilosophyResponsibility

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.