Evidence map›Paper›PMID 30796575›Full record

Observational studyEuropean radiology2019

Comparison between dynamic gadoxetate-enhanced MRI and

F Rassam, T Zhang, K P Cieslak, C Lavini, J Stoker, R J Bennink, T M van Gulik, L J van Vliet, J H Runge, F M Vos

Registry-linked trialOpen access · hybridAbstract readComparative StudyObservational Study
In one paragraph

Observational study in European radiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04692259 (Is It Possible To Predict PHLF? - Retrospective Analysis of Gadoxetate MRI Prior To Major Liver Resection), which is not on this map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
3.7field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04692259 naunknown statusnot on this mapstarted 2020, after this paper: background citation

Is It Possible To Predict PHLF? - Retrospective Analysis of Gadoxetate MRI Prior To Major Liver Resection

TypeinterventionalSponsorUniversity Hospital, LinkoepingRan2020 to 2024Enrolled200ConditionsMRI, Liver Resection, Liver Failure as A Complication of CareArmsMRI
3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

F RassamDepartment of Surgery, Cancer Center Amsterdam, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands. f.rassam@amc.uva.nl.ORCID http://orcid.org/0000-0001-8723-355X
T ZhangQuantitative Imaging Group, Faculty of Applied Sciences, Delft University of Technology, Delft, The Netherlands.
K P CieslakDepartment of Surgery, Cancer Center Amsterdam, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
C LaviniDepartments of Radiology and Nuclear Medicine, Cancer Center Amsterdam, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
J StokerDepartments of Radiology and Nuclear Medicine, Cancer Center Amsterdam, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
R J BenninkDepartments of Radiology and Nuclear Medicine, Cancer Center Amsterdam, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
T M van GulikDepartment of Surgery, Cancer Center Amsterdam, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
L J van VlietQuantitative Imaging Group, Faculty of Applied Sciences, Delft University of Technology, Delft, The Netherlands.
J H RungeDepartments of Radiology and Nuclear Medicine, Cancer Center Amsterdam, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
F M VosQuantitative Imaging Group, Faculty of Applied Sciences, Delft University of Technology, Delft, The Netherlands.
Amsterdam University Medical Centers · NLDelft University of Technology · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo compare Gd-EOB-DTPA dynamic hepatocyte-specific contrast-enhanced MRI (DHCE-MRI) with

methodsPatients undergoing liver surgery and preoperative assessment of future remnant liver (FRL) function using

resultsA total of 20 patients were included. The HBS-derived MUR and the DHCE-MRI-derived mean Ki correlated strongly for both total and FRL function (Pearson r = 0.70, p = 0.001 and r = 0.89, p < 0.001 respectively). There was a strong agreement between the functional share determined with both modalities (ICC = 0.944, 95% CI 0.863-0.978, n = 20). There was a significant negative correlation between liver aminotransferases and bilirubin for both MUR and Ki.

conclusionsAssessment of liver function with DHCE-MRI is comparable with that of KEY POINTS: • Quantitative assessment of liver function using hepatobiliary scintigraphy is performed in the preoperative assessment of patients undergoing liver surgery in order to prevent posthepatectomy liver failure. • Gd-EOB-DTPA dynamic hepatocyte-specific contrast-enhanced MRI (DHCE-MRI) is an emerging method to quantify liver function and can serve as a potential alternative to hepatobiliary scintigraphy. • Assessment of liver function with dynamic gadoxetate-enhanced MRI is comparable with that of hepatobiliary scintigraphy and has the potential to be combined with diagnostic MRI imaging.

Indexed as

AgedFemaleGadolinium DTPAHepatectomyHumansLiverLiver DiseasesLiver Function TestsMagnetic Resonance ImagingMaleMiddle AgedPilot ProjectsProspective StudiesRadionuclide ImagingRadiopharmaceuticalsTomography, Emission-Computed, Single-PhotonGadolinium DTPAgadolinium ethoxybenzyl DTPARadiopharmaceuticalsGadolinium ethoxybenzyl DTPALiver function testsMagnetic resonance imagingTechnetium Tc 99m mebrofenin

Identifiers

PMID30796575
PMCPMC6682576
OpenAlexW2915752753

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.