Evidence map›Paper›PMID 30796534›Full record

ArticleMikrochimica acta2019

An aptamer-based four-color fluorometic method for simultaneous determination and imaging of alpha-fetoprotein, vascular endothelial growth factor-165, carcinoembryonic antigen and human epidermal growth factor receptor 2 in living cells.

Jiayao Xu, Wenting Chen, Ming Shi, Yong Huang, Lina Fang, Shulin Zhao, Lifang Yao, Hong Liang

Abstract read
PubMed Publisher
In one paragraph

Article in Mikrochimica acta, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 29 citations in OpenAlex.

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  5. Metal Nanoparticles/MoSACS applied materials & interfaces · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Jiayao XuKey Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Guangxi Normal University, Guilin, 541004, China.
Wenting ChenKey Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Guangxi Normal University, Guilin, 541004, China.
Ming ShiDepartment of Chemistry and Pharmacy, Guilin Normal College, Guilin, 541001, Guangxi, China.
Yong HuangKey Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Guangxi Normal University, Guilin, 541004, China. huangyong_2009@163.com.ORCID http://orcid.org/0000-0003-4270-9555
Lina FangKey Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Guangxi Normal University, Guilin, 541004, China.
Shulin ZhaoKey Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Guangxi Normal University, Guilin, 541004, China. zhaoshulin001@163.com.
Lifang YaoKey Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Guangxi Normal University, Guilin, 541004, China.
Hong LiangKey Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Guangxi Normal University, Guilin, 541004, China. hliang@gxnu.edu.cn.
Guangxi Normal University · CN

Funding

Key Laboratory of Bioorganic Chemistry and Molecular Engineering (CN) CMEMR2015-A08National Natural Science Foundations of China 21864005, 81460544Natural Science Foundation of Guangxi Province (CN) 2015GXNSFGA139003
6 · The paper itself

Abstract

The extraordinary fluorescence quenching capability of graphene oxide (GO) was coupled to the specific recognition capability of aptamers to design a four-color fluorescent nanoprobe for multiplexed detection and imaging of tumor-associated proteins in living cells. Specifically, alpha-fetoprotein (AFP), vascular endothelial growth factor-165 (VEGF

Indexed as

alpha-FetoproteinsAptamers, NucleotideBiosensing TechniquesCarcinoembryonic AntigenCell LineColorErb-b2 Receptor Tyrosine KinasesFluorescence Resonance Energy TransferFluorescent DyesGoldGraphiteHumansLimit of DetectionMolecular ImagingParticle SizeSurface Propertiesalpha-FetoproteinsAptamers, NucleotideCarcinoembryonic AntigenERBB2 protein, humanErb-b2 Receptor Tyrosine KinasesFluorescent DyesGoldgraphene oxideGraphiteVascular Endothelial Growth Factor AVEGFA protein, humanBiocompatibilityFluorescence quenchingFluorescence turn-onGraphene oxideLive cell imagingMolecular imagingMultiplexed detectionNanoprobesNanosensorsTumor-associated proteins

Identifiers

PMID30796534
OpenAlexW2917226906

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.