ArticleMikrochimica acta2019
Fluorometric determination of the activity of alkaline phosphatase and its inhibitors based on ascorbic acid-induced aggregation of carbon dots.
Article in Mikrochimica acta, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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5 citing papers in PubMed, 30 citations in OpenAlex.
- Ferroptosis in Cancer and Inflammatory Diseases: Mechanisms and Therapeutic Implications.MedComm · 2025Review
- Preparation of Anti-Aristolochic Acid I Monoclonal Antibody and Development of Chemiluminescent Immunoassay and Carbon Dot-Based Fluoroimmunoassay for Sensitive Detection of Aristolochic Acid I.Foods (Basel, Switzerland) · 2021Article
- An ultrasonic-assisted synthesis of leather-derived luminescent graphene quantum dots: catalytic reduction and switch on-off probe for nitro-explosives.RSC advances · 2020Article
- A ratiometric fluorescent assay for evaluation of alkaline phosphatase activity based on ionic liquid-functionalized carbon dots.Mikrochimica acta · 2020Article
- Fluorometric determination of the activity of alkaline phosphatase based on a system composed of WSMikrochimica acta · 2019Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
The authors describe a fluorometric method for determination of the activity of alkaline phosphatase (ALP) and its inhibitors. Nitrogen and boron co-doped carbon dots (C-dots) with excitation/emission peaks at 490/540 nm act as the fluorescent probe. The C-dots were prepared by hydrothermal carbonization starting from 3-aminophenylboronic acid as the sole precursor. On the basis of the boronic acid-triggered specific reaction with cis-diols, the boronic acid modified C-dots can bind to ascorbic acid that is generated by ALP-catalyzed hydrolysis of ascorbic acid 2-phosphate. This results in particle aggregation and quenching of fluorescence. If the ALP inhibitor Na
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