Evidence map›Paper›PMID 30796479›Full record

ArticleAbdominal radiology (New York)2019

MR elastography of liver at 3 Tesla: comparison of gradient-recalled echo (GRE) and spin-echo (SE) echo-planar imaging (EPI) sequences and agreement across stiffness measurements.

Chenyang Zhan, Stephan Kannengiesser, Hersh Chandarana, Matthias Fenchel, Justin Ream, Krishna Prasad Shanbhogue

Abstract readComparative Study
In one paragraph

Article in Abdominal radiology (New York), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Advances in Magnetic Resonance Elastography of Liver.Magnetic resonance imaging clinics of North America · 2020
    Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Chenyang ZhanDepartment of Radiology, NYU Langone Health, 660 First Ave, New York, NY, 10016, USA.
Stephan KannengiesserSiemens Healthcare GmbH, Erlangen, Germany.
Hersh ChandaranaDepartment of Radiology, NYU Langone Health, 660 First Ave, New York, NY, 10016, USA.
Matthias FenchelSiemens Healthineers, New York, USA.
Justin ReamDepartment of Radiology, NYU Langone Health, 660 First Ave, New York, NY, 10016, USA.
Krishna Prasad ShanbhogueDepartment of Radiology, NYU Langone Health, 660 First Ave, New York, NY, 10016, USA. Krishna.Shanbhogue@nyulangone.org.
NYU Langone Health · USSiemens Healthcare (Germany) · DESiemens Healthcare (United States) · US

Funding

TR&D 4: Revealing Microstructure: Biophysical modeling and validation for discovery and clinical careP41EB017183 · NIBIB · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Christopher M Collins · 2014 to 2026
$19.3M
NIBIB NIH HHS P41 EB017183
6 · The paper itself

Abstract

purposeTo compare 2D gradient-recalled echo (GRE) and 2D spin-echo (SE) echo-planar imaging (EPI) MR elastography (MRE) for measurement of hepatic stiffness in adult patients with known or suspected liver disease at 3 Tesla. MATERIALS AND

methodsThree hundred and eighty-seven consecutive patients underwent MRE of the liver at 3 Tesla with 2D-GRE and 2D-SE-EPI sequences. 'Mean liver stiffness (LS)' calculated by averaging 3 ROIs in the right lobe, 'Maximum LS' calculated by an ROI in the right lobe; and 'Freehand LS' calculated by an ROI in the entire liver were measured by two independent readers. Inter-observer and inter-class variability in stiffness measurements were assessed. Stiffness values were correlated with degree of liver fibrosis (METAVIR scores) in 97 patients who underwent biopsy. The diagnostic performance was compared by a receiver-operating characteristic analysis.

resultsThe technical failure rate was 2.8% for 2D-SE-EPI (11/387) and 4.1% for 2D-GRE (16/387, 9 had R

conclusionsHigh intra-class correlation and intra-reader correlation are seen on measured hepatic stiffness for both 2D-GRE and 2D-SE-EPI MRE. 2D-SE-EPI has lower failure rate. Diagnostic performance of both sequences is equivalent, with highest sensitivity for 2D-GRE Freehand stiffness measurement, and highest specificity 2D-GRE Maximum stiffness measurement.

Indexed as

BiopsyDiagnosis, DifferentialEcho-Planar ImagingElasticity Imaging TechniquesFemaleHumansLiver CirrhosisLiver DiseasesMagnetic Resonance ImagingMaleMiddle AgedReproducibility of ResultsSensitivity and SpecificityGRELiver fibrosisMR elastography (MRE)SE-EPI

Identifiers

PMID30796479
PMCPMC6927036
OpenAlexW2917213108

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.