ArticleScientific reports2019
Urinary metabolic variation analysis during pregnancy and application in Gestational Diabetes Mellitus and spontaneous abortion biomarker discovery.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT03246295 (Identification of Gestational Diabetes Mellitus Related Urinary Biomarkers Along Pregnancy), which is not on this map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Identification of Gestational Diabetes Mellitus Related Urinary Biomarkers Along Pregnancy (From Early Pregnancy to Postpartum) by Using Proteomics and Metabolomics Analysis
Who cites it
20 citing papers in PubMed.
- Urinary Metabolites during Pregnancy: A Literature Review.ACS nutrition science · 2026Review
- TidyMass2: advancing LC-MS untargeted metabolomics through metabolite origin inference and metabolic feature-based functional module analysis.Nature communications · 2026Article
- Analysis of metabolites in serum and villous tissue of missed abortion patients based on targeted metabolomics.Frontiers in endocrinology · 2026Article
- Metabolic profiling and early prediction models for gestational diabetes mellitus in PCOS and non-PCOS pregnant women.European journal of medical research · 2025Article
- Biological characteristics of pregnancy in captive Yangtze finless porpoises revealed by urinary metabolomics†.Biology of reproduction · 2024Article
- Disease specific urinary biomarkers in the central nervous system.Scientific reports · 2023Article
- Associations of maternal plasma and umbilical cord plasma metabolomics profiles with birth anthropometric measures.Pediatric research · 2023Article
- Exploration of urinary metabolite dynamicity for early detection of pregnancy in water buffaloes.Scientific reports · 2022Article
- Urinary metabolomics reveals the biological characteristics of early pregnancy in pigs.Porcine health management · 2022Article
- Metabolomics Based on Peripheral Blood Mononuclear Cells to Dissect the Mechanisms of Chaigui Granules for Treating Depression.ACS omega · 2022Article
- Urine and Serum Metabolomic Profiles Differ by Disease Activity in Pregnant Women With Inflammatory Bowel Diseases.Gastro hep advances · 2022Article
- Non-Invasive and Mechanism-Based Molecular Assessment of Endometrial Receptivity During the Window of Implantation: Current Concepts and Future Prospective Testing Directions.Frontiers in reproductive health · 2022Review
- Urinary Metabolomic Profile of Neonates Born to Women with Gestational Diabetes Mellitus.Metabolites · 2021Article
- Machine learning approaches to predict gestational age in normal and complicated pregnancies via urinary metabolomics analysis.Scientific reports · 2021Article
- Current progress in metabolomics of gestational diabetes mellitus.World journal of diabetes · 2021Review
- The threshold effect of factors associated with spontaneous abortion in human-assisted reproductive technology.Scientific reports · 2021Article
- Multi-Enzyme Supplementation Modifies the Gut Microbiome and Metabolome in Breeding Hens.Frontiers in microbiology · 2021Article
- The Investigation of Metabonomic Pathways of Serum of Iranian Women with Recurrent Miscarriage UsingBioMed research international · 2021Article
- Article
- Construction of Glycometabolism- and Hormone-Related lncRNA-Mediated Feedforward Loop Networks Reveals Global Patterns of lncRNAs and Drug Repurposing in Gestational Diabetes.Frontiers in endocrinology · 2020Article
Corrections and comments
- Erratum issued
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pregnancy is associated with the onset of many adaptation processes that are likely to change over the course of gestation. Understanding normal metabolites' variation with pregnancy progression is crucial for gaining insights of the key nutrients for normal fetal growth, and for comparative research of pregnancy-related complications. This work presents liquid chromatography-mass spectrum-based urine metabolomics study of 50 health pregnant women at three time points during pregnancy. The influence of maternal physiological factors, including age, BMI, parity and gravity to urine metabolome was explored. Additionally, urine metabolomics was applied for early prediction of two pregnancy complications, gestational diabetes mellitus and spontaneous abortion. Our results suggested that during normal pregnancy progression, pathways of steroid hormone biosynthesis and tyrosine metabolism were significantly regulated. BMI is a factor that should be considered during cross-section analysis. Application analysis discovered potential biomarkers for GDM in the first trimester with AUC of 0.89, and potential biomarkers for SA in the first trimester with AUC of 0.90. In conclusion, our study indicated that urine metabolome could reflect variations during pregnancy progression, and has potential value for pregnancy complications early prediction. The clinical trial number for this study is NCT03246295.
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