ArticleScientific reports2019
Application of metabolomics and molecular networking in investigating the chemical profile and antitrypanosomal activity of British bluebells (Hyacinthoides non-scripta).
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
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Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The anti-Trypanosoma activities of medicinal plants: A systematic review of the literature.Veterinary medicine and science · 2022Pooled it
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- Isolation and Characterization of Antimicrobial Agents From Ipomoea carnea via Bioactivity-Guided Fractionation, Supported by In Vitro and In Silico Studies.Chemistry & biodiversity · 2026Article
- Screening of Red Sea- and Mediterranean Sea-derived Actinomycetes for Antimicrobial and Antitumor activities: LC-ESI-HRMS-based Metabolomics Study.Microbial cell factories · 2025Article
- Comparative metabolites profiling of different solvent extracts of Asparagus species cladodes using liquid chromatography-mass spectrometry-based metabolomics and molecular networking.Phytochemical analysis : PCA · 2025Article
- Statistical analysis of feature-based molecular networking results from non-targeted metabolomics data.Nature protocols · 2025Article
- Fast mass spectrometry search and clustering of untargeted metabolomics data.Nature biotechnology · 2024Article
- Unraveling the interplay between root exudates, microbiota, and rhizosheath formation in pearl millet.Microbiome · 2024Article
- Targeting antimalarial metabolites from the actinomycetes associated with the Red Sea sponge Callyspongia siphonella using a metabolomic method.BMC microbiology · 2023Article
- Metabolomic Profiling, In Vitro Antimalarial Investigation and In Silico Modeling of the Marine Actinobacterium StrainAntibiotics (Basel, Switzerland) · 2022Article
- Biological Assay-Guided Fractionation and Mass Spectrometry-Based Metabolite Profiling ofPlants (Basel, Switzerland) · 2022Article
- Induction of apoptosis and cell cycle arrest in colorectal cancer cells by novel anticancer metabolites of Streptomyces sp. 801.Cancer cell international · 2022Article
- PeakBot: machine-learning-based chromatographic peak picking.Bioinformatics (Oxford, England) · 2022Article
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- Anti-cancer and antimicrobial potential of five soilRoyal Society open science · 2022Article
- Advancements in capturing and mining mass spectrometry data are transforming natural products research.Natural product reports · 2021Review
- Identification of α-Glucosidase Inhibitors from Leaf Extract of Pepper (Metabolites · 2021Article
- Soybean-associated endophytic fungi as potential source for anti-COVID-19 metabolites supported by docking analysis.Journal of applied microbiology · 2021Article
- Feature-based molecular networking for identification of organic micropollutants including metabolites by non-target analysis applied to riverbank filtration.Analytical and bioanalytical chemistry · 2021Article
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5 authors.
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Abstract
Bulb, leaf, scape and flower samples of British bluebells (Hyacinthoides non-scripta) were collected regularly for one growth period. Methanolic extracts of freeze-dried and ground samples showed antitrypanosomal activity, giving more than 50% inhibition, for 20 out of 41 samples. High-resolution mass spectrometry was used in the dereplication of the methanolic extracts of the different plant parts. The results revealed differences in the chemical profile with bulb samples being distinctly different from all aerial parts. High molecular weight metabolites were more abundant in the flowers, shoots and leaves compared to smaller molecular weight ones in the bulbs. The anti-trypanosomal activity of the extracts was linked to the accumulation of high molecular weight compounds, which were matched with saponin glycosides, while triterpenoids and steroids occurred in the inactive extracts. Dereplication studies were employed to identify the significant metabolites via chemotaxonomic filtration and considering their previously reported bioactivities. Molecular networking was implemented to look for similarities in fragmentation patterns between the isolated saponin glycoside at m/z 1445.64 [M + formic-H]
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