ArticleScientific reports2019
Using resting-state DMN effective connectivity to characterize the neurofunctional architecture of empathy.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- Individualized Prediction of Females' Empathic Concern from Intrinsic Brain Activity within General Network of State Empathy.Cognitive, affective & behavioral neuroscience · 2022Pooled it
- Atypical Social Behavior is Predicted by Overconnectivity Between Salience and Default Mode Networks in Autism Spectrum Disorder.Journal of autism and developmental disorders · 2026Article
- Large-scale neural network compensation associated with camouflaging in trait autism and its potential mental health costs.Molecular autism · 2026Article
- Concerning the circadian rhythms of prolactin, its secretion timing, and regulation of the affiliative mind.Neuroscience and biobehavioral reviews · 2025Review
- The Brain That Understands Diversity: A Pilot Study Focusing on the Triple Network.Brain sciences · 2025Article
- A Novel Directed Seed-Based Connectivity Analysis Toolbox Applied to Human and Marmoset Resting-State FMRI.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Posterior default mode network is associated with the social performance in male children with autism spectrum disorder: A dynamic causal modeling analysis based on triple-network model.Human brain mapping · 2024Article
- Biobehavior Life Regulation (BLR) scale for living well in chronic pain: Preliminary scale development and validation.PloS one · 2024Article
- Empathy and resting-state functional connectivity in children.Neuroimage. Reports · 2022Article
- Associated functional network connectivity between callous-unemotionality and cognitive and affective empathy.Journal of affective disorders · 2022Article
- Effective connectivity of the human mirror neuron system during social cognition.Social cognitive and affective neuroscience · 2022Article
- Associations between Family Functioning and Maternal Behavior on Default Mode Network Connectivity in School-Age Children.International journal of environmental research and public health · 2022Article
- Intrinsic Shapes of Empathy: Functional Brain Network Topology Encodes Intersubjective Experience and Awareness Traits.Brain sciences · 2022Article
- From descriptive connectome to mechanistic connectome: Generative modeling in functional magnetic resonance imaging analysis.Frontiers in human neuroscience · 2022Review
- Hypothalamic effective connectivity at rest is associated with body weight and energy homeostasis.Network neuroscience (Cambridge, Mass.) · 2022Article
- Article
- Interplay Between the Salience and the Default Mode Network in a Social-Cognitive Task Toward a Close Other.Frontiers in psychiatry · 2021Article
- Interoception and Empathy Impact Perspective Taking.Frontiers in psychology · 2020Article
- Association Between Trait Empathy and Resting Brain Activity in Women With Primary Dysmenorrhea During the Pain and Pain-Free Phases.Frontiers in psychiatry · 2020Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neuroimaging studies in social neuroscience have largely relied on functional connectivity (FC) methods to characterize the functional integration between different brain regions. However, these methods have limited utility in social-cognitive studies that aim to understand the directed information flow among brain areas that underlies complex psychological processes. In this study we combined functional and effective connectivity approaches to characterize the functional integration within the Default Mode Network (DMN) and its role in self-perceived empathy. Forty-two participants underwent a resting state fMRI scan and completed a questionnaire of dyadic empathy. Independent Component Analysis (ICA) showed that higher empathy scores were associated with an increased contribution of the medial prefrontal cortex (mPFC) to the DMN spatial mode. Dynamic causal modelling (DCM) combined with Canonical Variance Analysis (CVA) revealed that this association was mediated indirectly by the posterior cingulate cortex (PCC) via the right inferior parietal lobule (IPL). More specifically, in participants with higher scores in empathy, the PCC had a greater effect on bilateral IPL and the right IPL had a greater influence on mPFC. These results highlight the importance of using analytic approaches that address directed and hierarchical connectivity within networks, when studying complex psychological phenomena, such as empathy.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.