Evidence map›Paper›PMID 30796226›Full record

ArticleNature communications2019

Prototype of running clinical trials in an untrustworthy environment using blockchain.

Daniel R Wong, Sanchita Bhattacharya, Atul J Butte

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 5 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Applications of Blockchain in the Medical Field: Narrative Review.Journal of medical Internet research · 2021
    Pooled it
  4. Pooled it
  5. Pooled it
  6. Article
  7. Enhancing Cancer Care through Blockchain Technology.Asian Pacific journal of cancer prevention : APJCP · 2025
    Review
  8. Review
  9. Article
  10. Decentralized Clinical Trials in Early Drug Development-A Framework Proposal.Journal of immunotherapy and precision oncology · 2024
    Review
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Is blockchain ready for orthopaedics? A systematic review.Journal of clinical orthopaedics and trauma · 2021
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Daniel R WongBakar Computational Health Sciences Institute, University of California, San Francisco, CA, 94158, USA.
Sanchita BhattacharyaBakar Computational Health Sciences Institute, University of California, San Francisco, CA, 94158, USA.
Atul J ButteBakar Computational Health Sciences Institute, University of California, San Francisco, CA, 94158, USA. atul.butte@ucsf.edu.ORCID http://orcid.org/0000-0002-7433-2740

Funding

NIH HHS HHSN316201200036W
6 · The paper itself

Abstract

Monitoring and ensuring the integrity of data within the clinical trial process is currently not always feasible with the current research system. We propose a blockchain-based system to make data collected in the clinical trial process immutable, traceable, and potentially more trustworthy. We use raw data from a real completed clinical trial, simulate the trial onto a proof of concept web portal service, and test its resilience to data tampering. We also assess its prospects to provide a traceable and useful audit trail of trial data for regulators, and a flexible service for all members within the clinical trials network. We also improve the way adverse events are currently reported. In conclusion, we advocate that this service could offer an improvement in clinical trial data management, and could bolster trust in the clinical research process and the ease at which regulators can oversee trials.

Indexed as

Quality ControlClinical Trials as TopicData CollectionDelivery of Health CareHumansMedical AuditProof of Concept Study

Identifiers

PMID30796226
PMCPMC6384889

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.