Evidence map›Paper›PMID 30796181›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2019

The Protein Phosphatase Shp1 Regulates Invariant NKT Cell Effector Differentiation Independently of TCR and Slam Signaling.

Mayra Cruz Tleugabulova, Meng Zhao, Irene Lau, Meggie Kuypers, Clarissa Wirianto, Juan Mauricio Umaña, Qiaochu Lin, Mitchell Kronenberg, Thierry Mallevaey

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Development of αβ T Cells with Innate Functions.Advances in experimental medicine and biology · 2022
    Article
  5. Article
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Mayra Cruz TleugabulovaDepartment of Immunology, University of Toronto, Toronto, Ontario M5S 1A8, Canada.
Meng ZhaoDivision of Developmental Immunology, La Jolla Institute for Immunology, La Jolla, CA 92037.
Irene LauDepartment of Immunology, University of Toronto, Toronto, Ontario M5S 1A8, Canada.
Meggie KuypersDepartment of Immunology, University of Toronto, Toronto, Ontario M5S 1A8, Canada.
Clarissa WiriantoDepartment of Immunology, University of Toronto, Toronto, Ontario M5S 1A8, Canada.
Juan Mauricio UmañaDepartment of Immunology, University of Toronto, Toronto, Ontario M5S 1A8, Canada.
Qiaochu LinDepartment of Immunology, University of Toronto, Toronto, Ontario M5S 1A8, Canada.
Mitchell KronenbergDivision of Developmental Immunology, La Jolla Institute for Immunology, La Jolla, CA 92037.
Thierry MallevaeyDepartment of Immunology, University of Toronto, Toronto, Ontario M5S 1A8, Canada; thierry.mallevaey@utoronto.ca.

Funding

Rheumatic Diseases Research Training GrantT32AR064194 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GARY S FIRESTEIN, Monica Guma · 2013 to 2026
$3.8M
Differentiation of subsets of NKT cellsR01AI071922 · NIAID · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI KRONENBERG, MITCHELL · 2016 to 2020
$2.7M
CIHR MOP–114911NIAID NIH HHS R01 AI071922NIAMS NIH HHS T32 AR064194
6 · The paper itself

Abstract

Invariant NKT (iNKT) cells are innate lipid-reactive T cells that develop and differentiate in the thymus into iNKT1/2/17 subsets, akin to T

Indexed as

AnimalsCell DifferentiationCytokinesMiceMice, KnockoutNatural Killer T-CellsProtein Tyrosine Phosphatase, Non-Receptor Type 6Receptors, Antigen, T-CellSignaling Lymphocytic Activation Molecule Family Member 1Signal TransductionCytokinesProtein Tyrosine Phosphatase, Non-Receptor Type 6Ptpn6 protein, mouseReceptors, Antigen, T-CellSignaling Lymphocytic Activation Molecule Family Member 1Slamf1 protein, mouse

Identifiers

PMID30796181
PMCPMC6457124

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.