Evidence map›Paper›PMID 30796169›Full record

ArticleJournal of nuclear medicine : official publication, Society of Nuclear Medicine2019

Molecular Imaging of the Glomerulus via Mesangial Cell Uptake of Radiolabeled Tilmanocept.

Zhengtao Qin, Carl K Hoh, Emilia S Olson, Amin Haghighat Jahromi, David J Hall, Christopher V Barback, Young-Hyun You, Motoko Yanagita, Kumar Sharma, David R Vera

Open access · bronzeAbstract read
In one paragraph

Article in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Review
  6. Review
  7. Non-invasive molecular imaging of kidney diseases.Nature reviews. Nephrology · 2021
    Review
  8. Review
  9. The next era of renal radionuclide imaging: novel PET radiotracers.European journal of nuclear medicine and molecular imaging · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Zhengtao QinDepartment of Radiology, University of California, San Diego, La Jolla, California.
Carl K HohDepartment of Radiology, University of California, San Diego, La Jolla, California.
Emilia S OlsonDepartment of Radiology, University of California, San Diego, La Jolla, California.
Amin Haghighat JahromiDepartment of Radiology, University of California, San Diego, La Jolla, California.
David J HallDepartment of Radiology, University of California, San Diego, La Jolla, California.
Christopher V BarbackDepartment of Radiology, University of California, San Diego, La Jolla, California.
Young-Hyun YouCenter for Renal Translational Medicine, University of California, San Diego, La Jolla, California.
Motoko YanagitaDepartment of Nephology, Kyoto University, Kyoto, Japan.
Kumar SharmaCenter for Renal Translational Medicine, University of California, San Diego, La Jolla, California.
David R VeraDepartment of Radiology, University of California, San Diego, La Jolla, California dvera@ucsd.edu.
University of California, San Diego · USKyoto University · JP

Funding

Targeted Smart Nanoplatforms for Multimode ImagingP50CA128346 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CORR, MARY P · 2008 to 2012
$6.9M
Novel Paradigms in Diabetic ComplicationsDP3DK094352 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SHARMA, KUMAR · 2011 to 2011
$6.0M
Spatial Multi-Omics to Profile Metabolic Pathways for Kidney DiseaseU01DK114920 · NIDDK · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Christopher R Anderton, Kumar Sharma · 2022 to 2026
$3.9M
Traning Clinical Scientists in Radiological ImagingT32EB005970 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Eric Y Chang, Rebecca Ann Rakow-Penner · 2007 to 2026
$3.2M
NCI NIH HHS P50 CA128346NIBIB NIH HHS T32 EB005970NIDDK NIH HHS DP3 DK094352NIDDK NIH HHS U01 DK114920
6 · The paper itself

Abstract

An unmet need for the clinical management of chronic kidney disease is a predictive tool of kidney function during the first decade of the disease, when there is silent loss of glomerular function. The objective of this study was to demonstrate receptor-mediated binding of tilmanocept to CD206 within the kidney and provide evidence of kinetic sensitivity of this binding to renal function.

Indexed as

Positron-Emission TomographyTomography, Emission-Computed, Single-PhotonAnimalsDextransImmunohistochemistryInjections, IntravenousKidney GlomerulusKineticsLectins, C-TypeLiverLymph NodesMaleMannose-Binding LectinsMannose ReceptorMesangial CellsMiceDextransgallium-diethylenetriaminepentaacetic acid-mannosyl-dextranLectins, C-TypeMannose-Binding LectinsMannose ReceptorRadiopharmaceuticalsReceptors, Cell SurfaceTechnetium Tc 99m Pentetate68Ga-tilmanocept99mTc-tilmanoceptkidney imagingmesangial cells

Identifiers

PMID30796169
PMCPMC6910642
OpenAlexW2916989139

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.