Evidence map›Paper›PMID 30796165›Full record

ArticleJournal of nuclear medicine : official publication, Society of Nuclear Medicine2019

Early Phase I Study of a

Yan Xing, Gitasha Chand, Changchun Liu, Gary J R Cook, Jim O'Doherty, Lingzhou Zhao, Nicholas C L Wong, Levente K Meszaros, Hong Hoi Ting, Jinhua Zhao

Registry-linked trialOpen access · hybridAbstract readClinical Trial, Phase I
In one paragraph

Article in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04992715 (A Single-arm, Phase II Study to Evaluate PD-L1 Expression in Non-Small Cell Lung Cancer Using the 99mTc Labelled Anti-PD-L1 Single Domain Antibody), which is not on this map. Cited by 97 papers.

0numbers the graph read from it
0cells of the map it votes in
97citing papers in PubMed
9.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04992715 phase2unknown statusnot on this mapstarted 2022, after this paper: background citation

A Single-arm, Phase II Study to Evaluate PD-L1 Expression in Non-Small Cell Lung Cancer Using the 99mTc Labelled Anti-PD-L1 Single Domain Antibody (NM-01)

TypeinterventionalSponsorNanoMab Technology (UK) LimitedRan2022 to 2023Enrolled15ConditionsNon-Small Cell Lung CancerArms[99mTc]-NM01 SPECT/CT
3 · Its place in the literature

Who cites it

97 citing papers in PubMed, 158 citations in OpenAlex.

  1. Trial
  2. PD-L1 imaging with [British journal of cancer · 2025
    Trial
  3. Challenges in tracer development for tumor microenvironment (TME) imaging.European journal of nuclear medicine and molecular imaging · 2026
    Review
  4. Review
  5. Two faces of Amitriptyline in anMolecular and clinical oncology · 2026
    Article
  6. Article
  7. Affinity- and Format-Dependent Pharmacokinetics ofPharmaceuticals (Basel, Switzerland) · 2026
    Article
  8. Evaluation of albumin-binding PD-L1-targeted VHH for PET imaging in colorectal cancer.American journal of nuclear medicine and molecular imaging · 2026
    Article
  9. Review
  10. Article
  11. Article
  12. EJNMMI radiopharmacy and chemistry · 2025
    Article
  13. Preclinical and first‑in‑human evaluation of [European journal of nuclear medicine and molecular imaging · 2025
    Article
  14. Radiotheranostic landscape: A review of clinical and preclinical development.European journal of nuclear medicine and molecular imaging · 2025
    Review
  15. Trends in nanobody radiotheranostics.European journal of nuclear medicine and molecular imaging · 2025
    Review
  16. Collagen Hybridizing Peptide-Based Radiotracers for Molecular Imaging of Collagen Turnover in Pulmonary Fibrosis.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2025
    Article
  17. Article
  18. Preclinical evaluation and preliminary clinical study ofCancer imaging : the official publication of the International Cancer Imaging Society · 2025
    Article
  19. Article
  20. Review

37 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 3 countries.

Yan XingDepartment of Nuclear Medicine, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, People's Republic of China.
Gitasha ChandDepartment of Nuclear Medicine, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, People's Republic of China.
Changchun LiuDepartment of Nuclear Medicine, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, People's Republic of China.
Gary J R CookDepartment of Cancer Imaging, School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom.
Jim O'DohertyDepartment of Molecular Imaging, Sidra Medicine, Doha, Qatar; and.
Lingzhou ZhaoDepartment of Nuclear Medicine, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, People's Republic of China.
Nicholas C L WongNanomab Technology Limited, Shanghai, People's Republic of China.
Levente K MeszarosNanomab Technology Limited, Shanghai, People's Republic of China.
Hong Hoi TingNanomab Technology Limited, Shanghai, People's Republic of China hhting@nano-mab.com.
Jinhua ZhaoDepartment of Nuclear Medicine, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, People's Republic of China.
Shanghai First People's Hospital · CNKing's College London · GBQatar Airways (Qatar) · QA

Funding

Cancer Research UK 16463Cancer Research UK 20265Medical Research Council C1519/A16463Wellcome Trust WT203148/Z/16/Z
6 · The paper itself

Abstract

Immunotherapy with checkpoint inhibitor programmed cell death 1 (PD-1)/programmed death ligand-1 (PD-L1) antibodies demonstrates improvements in treatment of advanced non-small cell lung cancer. Treatment stratification depends on immunohistochemical PD-L1 measurement of biopsy material, an invasive method that does not account for spatiotemporal heterogeneity. Using a single-domain antibody, NM-01, against PD-L1, radiolabeled site-specifically with

Indexed as

Single Photon Emission Computed Tomography Computed TomographyAdultAgedB7-H1 AntigenBiopsyCarcinoma, Non-Small-Cell LungFemaleHistidineHumansImmunohistochemistryImmunotherapyLung NeoplasmsLymphatic MetastasisMaleMiddle AgedOligopeptidesB7-H1 AntigenCD274 protein, humanHis-His-His-His-His-HisHistidineOligopeptidesTechnetiumearly phase Inon–small cell lung cancerPD-L1single domain antibody (sdAb)SPECT/CT

Identifiers

PMID30796165
PMCPMC6735283
OpenAlexW2917613252

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.