SynthesisNeurology2019
Genome-wide association meta-analysis of functional outcome after ischemic stroke.
Synthesis in Neurology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 97 papers, 6 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
97 citing papers in PubMed, 6 syntheses or guidelines pooled it, 170 citations in OpenAlex.
- Inflammatory cytokines are associated with stroke and risk factors of cerebrovascular diseases: a Mendelian randomization study.Mammalian genome : official journal of the International Mammalian Genome Society · 2025Pooled it
- DNA methylation and stroke prognosis: an epigenome-wide association study.Clinical epigenetics · 2024Pooled it
- Serum uric acid and prognosis of ischemic stroke: Cohort study, meta-analysis and Mendelian randomization study.European stroke journal · 2024Pooled it
- Genetic liability to migraine and functional outcome after ischemic stroke.European stroke journal · 2023Pooled it
- Pooled it
- Altered methylation pattern in EXOC4 is associated with stroke outcome: an epigenome-wide association study.Clinical epigenetics · 2022Pooled it
- Article
- Next-Generation Stroke Biomarkers: Bridging the Gap Between Innovation and Translation.Journal of clinical medicine · 2026Review
- Causal association between air pollution and functional outcome after ischemic stroke: Evidence from 2-sample MR study.Medicine · 2026Article
- Multi-Omics Integration Reveals That SN-011 Targets JUNB to Upregulate ADGRE5 and Restore Vascular Endothelial Cell Communication in Ischemic Stroke.Chemical biology & drug design · 2026Article
- Leveraging Mendelian randomization to inform drug discovery and development for ischemic stroke.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026Review
- Molecular heterogeneity in human stroke - What can we learn from the peripheral blood transcriptome?Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026Review
- APOE and Cerebral Microbleeds: Insights Into Causal Proteins and Therapeutic Targets.Brain and behavior · 2026Article
- Genetically Determined Levels of Inflammation-Related Proteins and Functional Outcome After Ischemic Stroke: A Mendelian Randomization Study.Journal of stroke · 2026Article
- The association of a common HFE gene variant with stroke disability utilizing predictive machine learning and electronic health records.Scientific reports · 2026Article
- Genomic insights into stroke recovery: cross-phenotype associations.Brain communications · 2026Article
- Genetically Elevated Neutrophil Count Is Associated with Poor Outcome Following Ischemic Stroke: A Mendelian Randomization Study.Molecular neurobiology · 2025Article
- A Mendelian randomization and animal study on the causal relationship between gut microbiota and ischemic stroke.Journal of thrombosis and thrombolysis · 2025Article
- Lack of association between the rs1842681 polymorphism of the LOC105372028 gene and functional outcomes after stroke.Scientific reports · 2025Article
- Causal Association of Free Triiodothyronine Level with Ischemic Stroke Outcome: A Mendelian Randomization Study.Life (Basel, Switzerland) · 2025Article
37 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
33 authors.
Funding
Abstract
objectiveTo discover common genetic variants associated with poststroke outcomes using a genome-wide association (GWA) study.
methodsThe study comprised 6,165 patients with ischemic stroke from 12 studies in Europe, the United States, and Australia included in the GISCOME (Genetics of Ischaemic Stroke Functional Outcome) network. The primary outcome was modified Rankin Scale score after 60 to 190 days, evaluated as 2 dichotomous variables (0-2 vs 3-6 and 0-1 vs 2-6) and subsequently as an ordinal variable. GWA analyses were performed in each study independently and results were meta-analyzed. Analyses were adjusted for age, sex, stroke severity (baseline NIH Stroke Scale score), and ancestry. The significance level was
resultsWe identified one genetic variant associated with functional outcome with genome-wide significance (modified Rankin Scale scores 0-2 vs 3-6,
conclusionsIn this large GWA study on functional outcome after ischemic stroke, we report one significant variant and several variants with suggestive association to outcome 3 months after stroke onset with plausible mechanistic links to poststroke recovery. Future replication studies and exploration of potential functional mechanisms for identified genetic variants are warranted.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.