ArticleApplied and environmental microbiology2019
Coculturing Bacteria Leads to Reduced Phenotypic Heterogeneities.
Article in Applied and environmental microbiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Emergent phenotypic heterogeneity in synthetic cross-feeding consortia driven by heterogeneous metabolite distribution.National science review · 2026Article
- Community Dynamics Drive Calcium Carbonate Production in an Enriched Consortium of Soil Microbes.Microbial ecology · 2025Article
- Single-cell analysis of lipopolysaccharide-mediated heterogeneity in Escherichia coli adhesion and mechanics.Archives of microbiology · 2025Article
- Article
- Exploring sub-species variation in food microbiomes: a roadmap to reveal hidden diversity and functional potential.Applied and environmental microbiology · 2025Review
- Quantifying synthetic bacterial community composition with flow cytometry: efficacy in mock communities and challenges in co-cultures.mSystems · 2025Article
- Droplet microfluidics for single-cell studies: a frontier in ecological understanding of microbiomes.FEMS microbiology reviews · 2025Review
- Extensive cellular multi-tasking withinmSystems · 2023Article
- Opportunities in optical and electrical single-cell technologies to study microbial ecosystems.Frontiers in microbiology · 2023Review
- Mode of killing determines the necrotrophic response of oral bacteria.Journal of oral microbiology · 2023Article
- Controlling microbial co-culture based on substrate pulsing can lead to stability through differential fitness advantages.PLoS computational biology · 2022Article
- Metabolic Synergy between Human SymbiontsMicrobiology spectrum · 2022Article
- Fast quantification of gut bacterial species in cocultures using flow cytometry and supervised classification.ISME communications · 2022Article
- Removal of primary nutrient degraders reduces growth of soil microbial communities with genomic redundancy.Frontiers in microbiology · 2022Article
- Compound Raman microscopy for rapid diagnosis and antimicrobial susceptibility testing of pathogenic bacteria in urine.Frontiers in microbiology · 2022Article
- Predicting the Presence and Abundance of Bacterial Taxa in Environmental Communities through Flow Cytometric Fingerprinting.mSystems · 2021Article
- Microbial phenomics linking the phenotype to fonction: The potential of Raman spectroscopy.Journal of microbiology (Seoul, Korea) · 2021Review
- PhenoGMM: Gaussian Mixture Modeling of Cytometry Data Quantifies Changes in Microbial Community Structure.mSphere · 2021Article
- Interaction study of Pasteurella multocida with culturable aerobic bacteria isolated from porcine respiratory tracts using coculture in conditioned media.BMC microbiology · 2021Article
- Biodiversity of marine microbes is safeguarded by phenotypic heterogeneity in ecological traits.PloS one · 2021Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Isogenic bacterial populations are known to exhibit phenotypic heterogeneity at the single-cell level. Because of difficulties in assessing the phenotypic heterogeneity of a single taxon in a mixed community, the importance of this deeper level of organization remains relatively unknown for natural communities. In this study, we have used membrane-based microcosms that allow the probing of the phenotypic heterogeneity of a single taxon while interacting with a synthetic or natural community. Individual taxa were studied under axenic conditions, as members of a coculture with physical separation, and as a mixed culture. Phenotypic heterogeneity was assessed through both flow cytometry and Raman spectroscopy. Using this setup, we investigated the effect of microbial interactions on the individual phenotypic heterogeneities of two interacting drinking water isolates. Through flow cytometry we have demonstrated that interactions between these bacteria lead to a reduction of their individual phenotypic diversities and that this adjustment is conditional on the bacterial taxon. Single-cell Raman spectroscopy confirmed a taxon-dependent phenotypic shift due to the interaction. In conclusion, our data suggest that bacterial interactions may be a general driver of phenotypic heterogeneity in mixed microbial populations.
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