Evidence map›Paper›PMID 30795913›Full record

ArticleMolecular metabolism2019

Functional peroxisomes are required for β-cell integrity in mice.

Ritesh Kumar Baboota, Abhijit Babaji Shinde, Katleen Lemaire, Marc Fransen, Stefan Vinckier, Paul P Van Veldhoven, Frans Schuit, Myriam Baes

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular metabolism, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 34 citations in OpenAlex.

  1. Article
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  8. The peroxisome: an update on mysteries 3.0.Histochemistry and cell biology · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Ritesh Kumar BabootaKU Leuven - University of Leuven, Department of Pharmaceutical and Pharmacological Sciences, Laboratory of Cell Metabolism, B-3000, Leuven, Belgium.
Abhijit Babaji ShindeKU Leuven - University of Leuven, Department of Pharmaceutical and Pharmacological Sciences, Laboratory of Cell Metabolism, B-3000, Leuven, Belgium.
Katleen LemaireKU Leuven - University of Leuven, Department of Cellular and Molecular Medicine, Gene Expression Unit, B-3000, Leuven, Belgium.
Marc FransenKU Leuven - University of Leuven, Department of Cellular and Molecular Medicine, Laboratory for Lipid Biochemistry and Protein Interactions, KU Leuven, B-3000, Leuven, Belgium.
Stefan VinckierVIB-KULeuven Centre for Cancer Biology, Laboratory of Angiogenesis and Vascular Metabolism, B-3000, Leuven, Belgium.
Paul P Van VeldhovenKU Leuven - University of Leuven, Department of Cellular and Molecular Medicine, Laboratory for Lipid Biochemistry and Protein Interactions, KU Leuven, B-3000, Leuven, Belgium.
Frans SchuitKU Leuven - University of Leuven, Department of Cellular and Molecular Medicine, Gene Expression Unit, B-3000, Leuven, Belgium.
Myriam BaesKU Leuven - University of Leuven, Department of Pharmaceutical and Pharmacological Sciences, Laboratory of Cell Metabolism, B-3000, Leuven, Belgium. Electronic address: Myriam.Baes@kuleuven.be.
KU Leuven · BEVIB-KU Leuven Center for Cancer Biology · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesPeroxisomes play a crucial role in lipid and reactive oxygen species metabolism, but their importance for pancreatic β-cell functioning is presently unknown. To examine the contribution of peroxisomal metabolism to β-cell homeostasis in mice, we inactivated PEX5, the import receptor for peroxisomal matrix proteins, in an inducible and β-cell restricted manner (Rip-Pex5

methodsAfter tamoxifen-induced recombination of the Pex5 gene at the age of 6 weeks, mice were fed either normal chow or a high-fat diet for 12 weeks and were subsequently phenotyped.

resultsIncreased levels of very long chain fatty acids and reduced levels of plasmalogens in islets confirmed impairment of peroxisomal fatty acid oxidation and ether lipid synthesis, respectively. The Rip-Pex5

conclusionsOur data indicate that normal peroxisome metabolism in β-cells is crucial to preserve their structure and function.

Indexed as

AnimalsInsulin-Secreting CellsMaleMiceMice, KnockoutMice, TransgenicPeroxisomesPeroxisome-Targeting Signal 1 ReceptorPeroxisome-Targeting Signal 1 ReceptorPex5 protein, mouseApoptosisDiabetesHigh-fat dietIsletPeroxisomeβ-cell

Identifiers

PMID30795913
PMCPMC6437690
OpenAlexW2914269374

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.