Evidence map›Paper›PMID 30795902›Full record

ArticleNeuron2019

Defining the Functional Role of Na

Lucy A McDermott, Greg A Weir, Andreas C Themistocleous, Andrew R Segerdahl, Iulia Blesneac, Georgios Baskozos, Alex J Clark, Val Millar, Liam J Peck, Daniel Ebner and 3 more

Open access · hybridAbstract read
In one paragraph

Article in Neuron, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 110 papers.

0numbers the graph read from it
0cells of the map it votes in
110citing papers in PubMed
11.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

110 citing papers in PubMed, 199 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. NaThe Journal of comparative neurology · 2026
    Article
  9. Article
  10. Shaping the Action Potential in Dorsal Root and Trigeminal Ganglia Neurons: Relevance to Pain Mechanisms.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Review
  11. Article
  12. Article
  13. Discovery of NaJournal of natural products · 2025
    Article
  14. Article
  15. Decoding Pain: Next-Generation In Vitro Systems for Mechanistic Insights and Drug Discovery.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Review
  16. Review
  17. Article
  18. Article
  19. Review
  20. Review

50 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Lucy A McDermottNuffield Department of Clinical Neurosciences, University of Oxford, Oxford OX3 9DU, UK.
Greg A WeirNuffield Department of Clinical Neurosciences, University of Oxford, Oxford OX3 9DU, UK.
Andreas C ThemistocleousNuffield Department of Clinical Neurosciences, University of Oxford, Oxford OX3 9DU, UK.
Andrew R SegerdahlNuffield Department of Clinical Neurosciences, University of Oxford, Oxford OX3 9DU, UK; Wellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford OX3 9DU, UK.
Iulia BlesneacNuffield Department of Clinical Neurosciences, University of Oxford, Oxford OX3 9DU, UK.
Georgios BaskozosNuffield Department of Clinical Neurosciences, University of Oxford, Oxford OX3 9DU, UK.
Alex J ClarkNuffield Department of Clinical Neurosciences, University of Oxford, Oxford OX3 9DU, UK.
Val MillarTarget Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7FZ, UK.
Liam J PeckNuffield Department of Clinical Neurosciences, University of Oxford, Oxford OX3 9DU, UK.
Daniel EbnerTarget Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7FZ, UK.
Irene TraceyNuffield Department of Clinical Neurosciences, University of Oxford, Oxford OX3 9DU, UK; Wellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford OX3 9DU, UK.
Jordi SerraDepartment of Clinical Neurophysiology, King's College Hospital, London SE5 9RS, UK.
David L BennettNuffield Department of Clinical Neurosciences, University of Oxford, Oxford OX3 9DU, UK. Electronic address: david.bennett@ndcn.ox.ac.uk.
University of Oxford · GBWellcome Centre for Integrative Neuroimaging · GBKing's College Hospital · GB

Funding

Wellcome Trust 202747/Z/16/Z
6 · The paper itself

Abstract

Loss-of-function mutations in Na

Indexed as

NociceptionAction PotentialsAdultAxonsCell LineCells, CulturedFemaleHumansInduced Pluripotent Stem CellsMaleMutationNAV1.7 Voltage-Gated Sodium ChannelNociceptorsPain Insensitivity, CongenitalRanvier's NodesSodium Channel BlockersNAV1.7 Voltage-Gated Sodium ChannelSCN9A protein, humanSodium Channel Blockerscongenital insensitivity to painCRISPRdrug developmentinduced pluripotent stem cellsmicroneurographyNa(V)1.7nociceptorpainSCN9Avoltage-gated sodium channel

Identifiers

PMID30795902
PMCPMC6424805
OpenAlexW2916814039

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.