Trial reportRespiratory research2019
Use of Berlin questionnaire in comparison to polysomnography and home sleep study in patients with obstructive sleep apnea.
Trial report in Respiratory research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01828216 (A Randomized Controlled Study Assessing the Role of an Ambulatory Approach Versus the Conventional Approach in Managing Suspected Obstructive Sleep Apnoea Syndrome), which is not on this map. Cited by 15 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Randomized Controlled Study Assessing the Role of an Ambulatory Approach Versus the Conventional Approach in Managing Suspected Obstructive Sleep Apnoea Syndrome
Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 37 citations in OpenAlex.
- Diagnostic utility of obstructive sleep apnea screening questionnaires: a comprehensive meta-analysis.Sleep & breathing = Schlaf & Atmung · 2024Pooled it
- Association between sleep-disordered breathing and periodontitis: a meta-analysis.Medicina oral, patologia oral y cirugia bucal · 2023Pooled it
- Sleep measurement and clinical impact in osteoarthritis and inflammatory arthritis: a scoping review.Rheumatology (Oxford, England) · 2026Article
- Modified Berlin Score for predicting sleep apnea in patients with acute ischemic stroke.BMC neurology · 2026Observational
- Illness perceptions of obstructive sleep apnea (OSA) and intention of performing clinical diagnostic examination for OSA in Chinese older adults.BMC public health · 2025Article
- Improving OSA screening efficiency with subjective questionnaires: integrating STOP-Bang, ESS, and Berlin.Frontiers in medicine · 2025Article
- Relationship between chronic rhinosinusitis and risk of obstructive sleep apnea.Scientific reports · 2024Article
- Comparative Study of Subjective and Objective Analysis in Diagnosis of Obstructive Sleep Apnea.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2023Article
- Impact of a Weight-Loss Rehabilitation Program on Sleep Apnea Risk and Subjective Sleepiness in Patients with Overweight/Obesity: The DietSleep Study.Journal of clinical medicine · 2022Article
- Validation of GOAL questionnaire as screening tool for clinical obstructive sleep apnea: A large sample study in China.Frontiers in neuroscience · 2022Article
- ENIGMA-Sleep: Challenges, opportunities, and the road map.Journal of sleep research · 2021Review
- Comparison of six assessment tools to screen for obstructive sleep apnea in patients with hypertension.Clinical cardiology · 2021Article
- Development and validation of a nomogram for predicting the risk of obstructive sleep apnea in patients with type 2 diabetes.Annals of translational medicine · 2020Article
- The Association of Obstructive Sleep Apnea Syndrome and Accident Risk in Heavy Equipment Operators.Medicina (Kaunas, Lithuania) · 2019Article
- Sleep disordered breathing from preschool to early adult age and its neurocognitive complications: A preliminary report.Sleep science (Sao Paulo, Brazil)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundObstructive sleep apnea syndrome (OSAS) is a common disorder with significant morbidity and mortality. We aimed to evaluate the predictive accuracy of the Berlin questionnaire in patients with suspected OSAS undergoing PSG in the sleep laboratory setting against those going through the Embletta™ portable diagnostic system (Embletta PDS) at home.
methodsPatients with suspected OSAS were recruited from respiratory clinics to complete Berlin questionnaire and Epworth Sleepiness Score (ESS). Patients were randomized to undergo either home-based sleep test (group A) or hospital-based polysomnography (PSG) (group B).
resultsThree hundreds and sixteen subjects with newly referred suspected OSAS were recruited and randomized into group A (n = 157) and group B (n = 159). The prevalence of moderate to severe OSAS defined as apnea-hypopnea index (AHI) ≥ 15/h was 54%. The Berlin questionnaire identified 69.7% (n = 99) of subjects as high risk in group A and 77.5% (n = 100) in group B. The sensitivity, specificity, negative predictive value (NPV), and positive predictive value (PPV) of the questionnaire to predict an AHI ≥ 15/h as diagnosed by PSG was 78, 23, 67 and 35%. When compared with Embletta PDS, the specificity and NPV increased to 48 and 63%. The area under the Receiver Operator Curve (ROC) based on PSG (AUC = 0.539, 95%CI 0.417, 0.661) and based on home Embletta (AUC = 0.712, 95%CI 0.617, 0.907).
conclusionsThe questionnaire was not reliable in predicting OSAS through PSG AHI whereas there was some predictive ability in discriminating patients with OSAS from normal subjects based on home Embletta sleep test.
trial registrationThe study was registered at ClinicalTrials.gov (Identifier: NCT01828216) on 10 April 2013.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.