ArticleBMC infectious diseases2019
Effects of the rotavirus vaccine program across age groups in the United States: analysis of national claims data, 2001-2016.
Article in BMC infectious diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 41 citations in OpenAlex.
- Mucosal Immunity: The Key to Combating Enteroviruses and Beyond.Journal of immunology research · 2026Review
- An Evaluation of Enteropathogen-Specific Disease Severity and Duration in Children With Acute Gastroenteritis.Pediatric emergency care · 2025Article
- Indirect Effects of Universal Infant Rotavirus Vaccination: A Narrative Systematic Review.Vaccines · 2025Review
- Pediatric Rotavirus Hospitalization Rates in the Military Health System Before and During the COVID-19 Pandemic.Vaccines · 2025Article
- Prevalence of Acute Gastroenteritis Enteropathogens Among Hospitalized Children in Jordan: A Single-Center Study.Viruses · 2025Article
- Article
- Household Transmission of Viral Acute Gastroenteritis Among Participants Within an Integrated Health Care Delivery System, 2014-2016.Open forum infectious diseases · 2023Article
- Variation in stool testing for children with acute gastrointestinal infections.Journal of hospital medicine · 2023Article
- The Economic Value of Rotavirus Vaccination When Optimally Implemented in a High-Income Country.Vaccines · 2023Article
- Predicting indirect effects of rotavirus vaccination programs on rotavirus mortality among children in 112 countries.NPJ vaccines · 2023Article
- Spatiotemporal Trends in Norovirus Outbreaks in the United States, 2009-2019.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2023Article
- Rotavirus genotypes and clinical outcome of natural infection based on vaccination status in the post-vaccine era.Human vaccines & immunotherapeutics · 2022Article
- Review
- Rotavirus vaccines: progress and new developments.Expert opinion on biological therapy · 2022Review
- Defining the Recipe for an Optimal Rotavirus Vaccine Introduction in a High-Income Country in Europe.Viruses · 2022Article
- Rotavirus Vaccination Likely to Be Cost Saving to Society in the United States.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021Article
- Impact of Rotavirus Vaccines on Gastroenteritis Hospitalizations in Western Australia: A Time-series Analysis.Journal of epidemiology · 2021Article
- Lessons Learned from Long-Term Assessment of Rotavirus Vaccination in a High-Income Country: The Case of the Rotavirus Vaccine Belgium Impact Study (RotaBIS).Infectious diseases and therapy · 2020Article
- Accounting for indirect protection in the benefit-risk ratio estimation of rotavirus vaccination in children under the age of 5 years, France, 2018.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2020Article
- Disease burden and seasonal impact of improving rotavirus vaccine coverage in the United States: A modeling study.PloS one · 2020Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe direct effectiveness of infant rotavirus vaccination implemented in 2006 in the United States has been evaluated extensively, however, understanding of population-level vaccine effectiveness (VE) is still incomplete.
methodsWe analyzed time series data on rotavirus gastroenteritis (RVGE) and all-cause acute gastroenteritis (AGE) hospitalization rates in the United States from the MarketScan® Research Databases for July 2001-June 2016. Individuals were grouped into ages 0-4, 5-9, 10-14, 15-24, 25-44, and 45-64 years. Negative binomial regression models were fitted to monthly RVGE and AGE data to estimate the direct, indirect, overall, and total VE.
resultsA total of 9211 RVGE and 726,528 AGE hospitalizations were analyzed. Children 0-4 years of age had the largest declines in RVGE hospitalizations with direct VE of 87% (95% CI: 83, 90%). Substantial indirect effects were observed across age groups and generally declined in each older group. Overall VE against RVGE hospitalizations for all ages combined was 69% (95% CI: 62, 76%). Total VE was highest among young children; a vaccinated child in the post-vaccine era has a 95% reduced risk of RVGE hospitalization compared to a child in the pre-vaccine era. We observed higher direct VE in odd post-vaccine years and an opposite pattern for indirect VE.
conclusionsVaccine benefits extended to unvaccinated individuals in all age groups, suggesting infants are important drivers of disease transmission across the population. Imperfect disease classification and changing disease incidence may lead to bias in observed direct VE.
trial registrationNot applicable.
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