Evidence map›Paper›PMID 30795731›Full record

ReviewTherapeutic advances in respiratory disease

Safety of tiotropium in patients with asthma.

Daniel Dusser, Francine M Ducharme

Open access · goldAbstract readReview
In one paragraph

Review in Therapeutic advances in respiratory disease. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.

  1. 2020 Brazilian Thoracic Association recommendations for the management of asthma.Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia
    Guideline
  2. Article
  3. Review
  4. Review
  5. Patterns of bronchodilator therapy in asthmatic outpatients.Journal of public health in Africa · 2023
    Article
  6. Tiotropium bromide as adjunct therapy in children with asthma: a clinical experience.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2021
    Article
  7. Article
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

Daniel DusserService de Pneumologie, Hôpital Cochin, AP-HP, Université Paris Descartes, 27 Rue du Faubourg Saint-Jacques, Sorbonne Paris Cité, Paris, 75014, France.ORCID 0000-0002-5820-3789
Francine M DucharmeDepartments of Pediatrics and of Social and Preventive Medicine, University of Montréal, Montréal, Canada Research Centre, CHU Sainte-Justine, Montréal, Canada.
Centre Hospitalier Universitaire Sainte-Justine · CAUniversité Paris Cité · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Given the high proportion of patients with asthma who remain uncontrolled despite controller treatment, there remains a need for the development of more effective treatment options with a proven safety and tolerability profile. Recently, asthma guidelines have evolved to incorporate new therapies, including long-acting muscarinic antagonists (LAMAs) and biologics. Here we focus on the safety profile of tiotropium, a LAMA, using data from the large-scale UniTinA-asthma

Indexed as

Administration, InhalationAdolescentAdultAgedAnimalsAnti-Asthmatic AgentsAsthmaBronchodilator AgentsChildCholinergic AntagonistsDose-Response Relationship, DrugGlucocorticoidsHumansTiotropium BromideAnti-Asthmatic AgentsBronchodilator AgentsCholinergic AntagonistsGlucocorticoidsTiotropium Bromideanticholinergicsasthmalong-acting muscarinic antagonistssafetytiotropium

Identifiers

PMID30795731
PMCPMC6391545
OpenAlexW2916686429

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.