Evidence map›Paper›PMID 30795645›Full record

ReviewChildren (Basel, Switzerland)2019

Multidisciplinary Pain Management for Pediatric Patients with Acute and Chronic Pain: A Foundational Treatment Approach When Prescribing Opioids.

Anava A Wren, Alexandra C Ross, Genevieve D'Souza, Christina Almgren, Amanda Feinstein, Amanda Marshall, Brenda Golianu

Registry-linked trialAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Children (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05708989 (Caudal vs. Pudendal Block for Early Postoperative Pain Control in a Pediatric Population Undergoing Lower Genitourinary Surgery), which is not on this map. Cited by 45 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05708989 phase4withdrawnnot on this mapstarted 2023, after this paper: background citation

Caudal vs. Pudendal Block for Early Postoperative Pain Control in a Pediatric Population Undergoing Lower Genitourinary Surgery

TypeinterventionalSponsorUniversity Hospitals Cleveland Medical CenterRan2023 to 2025Enrolled0ConditionsHypospadias, Penile Torsion, Chordee, PhimosisArmsCaudal Block, Ultrasound-guided Pudendal Block, Injectable 1 ml/kg of 0.25% ropivacaine with 1mcg/kg dexmedetomidine, Injection of 0.5 ml/kg per side of injectable 0.2-0.3% ropivacaine with 0.5 mcg/kg dexmetomedine.
3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Guideline
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Comparison of behavioural, physiological, and self-reported pain responses in Pakistani children with dental pain: a descriptive cross-sectional study.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2025
    Trial
  6. Trial
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Psoriasis.Nature reviews. Disease primers · 2025
    Review
  14. The Role of IR in Pediatric Pain and Palliation.Seminars in interventional radiology · 2025
    Review
  15. Review
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Anava A WrenDepartment of Pediatrics, Division of Pediatric Gastroenterology, Hepatology and Nutrition, Stanford University, Palo Alto, CA 94305, USA. awren2@stanford.edu.
Alexandra C RossDepartment of Pediatrics, Child and Adolescent Headache Program, University of California San Francisco, San Francisco, CA 94158, USA. alexandra.ross2@ucsf.edu.
Genevieve D'SouzaDepartment of Anesthesiology Perioperative and Pain Medicine, Stanford University, Palo Alto, CA 94305, USA. gdsouza@stanford.edu.
Christina AlmgrenDepartment of Anesthesiology Perioperative and Pain Medicine, Stanford University, Palo Alto, CA 94305, USA. calmgren@stanfordchildrens.org.
Amanda FeinsteinDepartment of Anesthesiology Perioperative and Pain Medicine, Stanford University, Palo Alto, CA 94305, USA. abfein@stanford.edu.
Amanda MarshallCentre for Clinical Brain Sciences, University of Edinburgh, Edinburgh EH16 4SB, UK. a.marshall-15@sms.ed.ac.uk.
Brenda GolianuDepartment of Anesthesiology Perioperative and Pain Medicine, Stanford University, Palo Alto, CA 94305, USA. bgolianu@stanford.edu.ORCID 0000-0003-0731-9535

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Opioid therapy is the cornerstone of treatment for acute procedural and postoperative pain and is regularly prescribed for severe and debilitating chronic pain conditions. Although beneficial for many patients, opioid therapy may have side effects, limited efficacy, and potential negative outcomes. Multidisciplinary pain management treatments incorporating pharmacological and integrative non-pharmacological therapies have been shown to be effective in acute and chronic pain management for pediatric populations. A multidisciplinary approach can also benefit psychological functioning and quality of life, and may have the potential to reduce reliance on opioids. The aims of this paper are to: (1) provide a brief overview of a multidisciplinary pain management approach for pediatric patients with acute and chronic pain, (2) highlight the mechanisms of action and evidence base of commonly utilized integrative non-pharmacological therapies in pediatric multidisciplinary pain management, and (3) explore the opioid sparing effects of multidisciplinary treatment for pediatric pain.

Indexed as

acupuncturecognitive behavioral therapyhypnosismindfulness-based stress reductionmultidisciplinary pain management strategiesnon-pharmacological therapyopioid reduction therapypain rehabilitation

Identifiers

PMID30795645
PMCPMC6406753

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.