Evidence map›Paper›PMID 30795632›Full record

ArticleMolecules (Basel, Switzerland)2019

Flavopereirine-An Alkaloid Derived from

João Victor da Silva E Silva, Heliton Patrick Cordovil Brigido, Kelly Cristina Oliveira de Albuquerque, Josiwander Miranda Carvalho, Jordano Ferreira Reis, Lara Vinhal Faria, Márlia Coelho-Ferreira, Fernando Tobias Silveira, Agnaldo da Silva Carneiro, Sandro Percário and 2 more

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
2.7field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.

  1. Activity of the genusFrontiers in pharmacology · 2022
    Pooled it
  2. Review
  3. Healing and leishmanicidal activity ofFrontiers in chemistry · 2025
    Article
  4. Article
  5. Frontiers in chemistry · 2024
    Article
  6. Alkaloid fromPharmaceuticals (Basel, Switzerland) · 2023
    Article
  7. Article
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 3 countries.

João Victor da Silva E SilvaPost-Graduate Program in Pharmaceutical Sciences, Federal University of Pará, Belém, 66075-110 PA, Brazil. jvssilva89@gmail.com.
Heliton Patrick Cordovil BrigidoPost-Graduate Program in Pharmaceutical Innovation, Federal University of Pará, Belém, 66075-110 PA, Brazil. helitom2009@hotmail.com.
Kelly Cristina Oliveira de AlbuquerquePost-Graduate Program in Pharmaceutical Sciences, Federal University of Pará, Belém, 66075-110 PA, Brazil. kellyoalbuquerque@hotmail.com.
Josiwander Miranda CarvalhoCollege of Chemistry, Federal University of Pará, Belém, 66075-110 PA, Brazil. mcwander@hotmail.com.
Jordano Ferreira ReisFaculty of Pharmacy, Federal University of Pará, Belém, 66075-110 PA, Brazil. jordanoreis@outlook.com.
Lara Vinhal FariaFaculty of Pharmacy, Federal University of Pará, Belém, 66075-110 PA, Brazil. laravf24@gmail.com.
Márlia Coelho-FerreiraEmílio Goeldi Paraense Museum, Coordination of Botany, Ministry of Science, Technology, Innovation and Communications. Belém, 66077-530 PA, Brazil. mcoelho@museu-goeldi.br.
Fernando Tobias SilveiraEvandro Chagas Institute, National Health Foundation, BR-316 Highway km 7, Ananindeua, 67030-000 PA, Brazil. fernandotobias@iec.pa.gov.br.
Agnaldo da Silva CarneiroFaculty of Pharmacy, Federal University of Pará, Belém, 66075-110 PA, Brazil. agsicar@yahoo.com.br.
Sandro PercárioUS Centers for Disease Control and Prevention (CDC), Atlanta, 30329 GA, USA. percario@ufpa.br.
Andrey Moacir do Rosário MarinhoCollege of Chemistry, Federal University of Pará, Belém, 66075-110 PA, Brazil. andrey@ufpa.br.
Maria Fâni DolabelaPost-Graduate Program in Pharmaceutical Sciences, Federal University of Pará, Belém, 66075-110 PA, Brazil. fanidolabela20@gmail.com.
Universidade Federal do Pará · BRCenters for Disease Control and Prevention · USFundação Oswaldo Cruz · BRInstituto Evandro Chagas · BRMuseu Paraense Emílio Goeldi · BR

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 310608/2013-9Conselho Nacional de Desenvolvimento Científico e Tecnológico Universal; 483894/2012-5
6 · The paper itself

Abstract

Chemotherapy is limited in the treatment of leishmaniasis due to the toxic effects of drugs, low efficacy of alternative treatments, and resistance of the parasite. This work assesses the in vitro activity of flavopereirine on promastigote cultures of

Indexed as

AntipainAntiprotozoal AgentsApocynaceaeCarbolinesCell SurvivalHumansIndole AlkaloidsInhibitory Concentration 50Leishmania mexicanaLife Cycle StagesMolecular Docking SimulationMolecular Dynamics SimulationPlant BarkPlant ExtractsProtozoan ProteinsSerine EndopeptidasesAntipainAntiprotozoal AgentsCarbolinesflavopereirineIndole Alkaloidsoligopeptidase BPlant ExtractsProtozoan ProteinsSerine EndopeptidasesapocynaceaeflavopereirineGeissospermum vellosiiin silico modelingleishmaniamedicinal chemistryoligopeptidase B

Identifiers

PMID30795632
PMCPMC6412932
OpenAlexW2915674411

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.