ArticleInternational journal of molecular sciences2019
Volta Phase Plate Cryo-EM Structure of the Human Heterodimeric Amino Acid Transporter 4F2hc-LAT2.
Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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Who cites it
12 citing papers in PubMed, 15 citations in OpenAlex.
- Structural basis for the substrate recognition and transport mechanism of the human yScience advances · 2025Article
- Cryo-EM structure of the human Asc-1 transporter complex.Nature communications · 2024Article
- Characterization of substrates and inhibitors of the human heterodimeric transporter 4F2hc-LAT1 using purified protein and the scintillation proximity radioligand binding assay.Frontiers in physiology · 2023Article
- Structure of the human heterodimeric transporter 4F2hc-LAT2 in complex with Anticalin, an alternative binding protein for applications in single-particle cryo-EM.Scientific reports · 2022Article
- Article
- Consensus mutagenesis approach improves the thermal stability of system xProtein science : a publication of the Protein Society · 2020Article
- The Heavy Chain 4F2hc Modulates the Substrate Affinity and Specificity of the Light Chains LAT1 and LAT2.International journal of molecular sciences · 2020Article
- Sub-Nanometer Cryo-EM Density Map of the Human Heterodimeric Amino Acid Transporter 4F2hc-LAT2.International journal of molecular sciences · 2020Article
- Cryo-EM structure of the human heteromeric amino acid transporter bScience advances · 2020Article
- Amino Acids Transport and Metabolism 2.0.International journal of molecular sciences · 2020Article
- LAT1 (SLC7A5) and CD98hc (SLC3A2) complex dynamics revealed by single-particle cryo-EM.Acta crystallographica. Section D, Structural biology · 2019Article
- Cryo-EM structure of the human L-type amino acid transporter 1 in complex with glycoprotein CD98hc.Nature structural & molecular biology · 2019Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Heteromeric amino acid transporters (HATs) are protein complexes that catalyze the transport of amino acids across plasma membranes. HATs are composed of two subunits, a heavy and a light subunit, which belong to the solute carrier (SLC) families SLC3 and SLC7. The two subunits are linked by a conserved disulfide bridge. Several human diseases are associated with loss of function or overexpression of specific HATs making them drug targets. The human HAT 4F2hc-LAT2 (SLC3A2-SLC7A8) is specific for the transport of large neutral L-amino acids and specific amino acid-related compounds. Human 4F2hc-LAT2 can be functionally overexpressed in the methylotrophic yeast
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Registered trials
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