Evidence map›Paper›PMID 30794947›Full record

ArticleThe ocular surface2019

The optimum temperature for the heat therapy for meibomian gland dysfunction.

Douglas Borchman

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The ocular surface, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Efficacy and safety of a vectored thermal pulsation system (Lipiflow®) in the treatment of meibomian gland dysfunction: a systematic review and meta-analysis.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Douglas BorchmanDepartment of Ophthalmology and Visual Sciences, University of Louisville, Louisville, KY, 40202, USA. Electronic address: borchman@louisville.edu.

Funding

Tear Film Lipid Compositional, Structural, Functional, Relationships, and Dry EyeR01EY026180 · NEI · UNIVERSITY OF LOUISVILLE · PI BORCHMAN, DOUGLAS · 2016 to 2020
$1.4M
NEI NIH HHS R01 EY026180
6 · The paper itself

Abstract

purposeNumerous devices have been developed to warm the eyelid as a therapy for Meibomian gland dysfunction. The optimum temperature for such therapy was determined.

methodsMeibum lipid disorder versus temperature was calculated from previously published phase transition parameters measured using infrared spectroscopy. Phase transitions parameters were calculated from meibum obtained from donors with Meibomian gland dysfunction (M

resultsHeating Mn to 40 °C increases the lipid disorder by 20.4%-90%. Heating the meibum another 4° increases the disorder to 95%. M

conclusionsHeating the eye lid above the phase transition temperature of meibum increases the disorder of meibum lipid which could ameliorate dry eye symptoms. The optimum temperature for disordering Mn and M

Indexed as

Hot TemperatureHumansHyperthermia, InducedLipid MetabolismLipidsMeibomian Gland DysfunctionMeibomian GlandsTearsLipidsDry eyeHeat therapyInfrared spectroscopyMeibumPhase transition

Identifiers

PMID30794947
PMCPMC6529265

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.