ArticleSleep2019
The neural tides of sleep and consciousness revealed by single-pulse electrical brain stimulation.
Article in Sleep, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Methodologies to detect cortico-cortical evoked potentials: a systematic review.Frontiers in human neuroscience · 2025Pooled it
- Network excitability of stimulation-induced spectral responses helps localize the seizure onset zone.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2024Article
- Effects of Targeted Memory Reactivation on Cortical Networks.Brain sciences · 2024Article
- Single-pulse electrical stimulation artifact removal using the novel matching pursuit-based artifact reconstruction and removal method (MPARRM).Journal of neural engineering · 2023Article
- Brain and brain-heart Granger causality during wakefulness and sleep.Frontiers in neuroscience · 2022Article
- Thalamic deep brain stimulation modulates cycles of seizure risk in epilepsy.Scientific reports · 2021Article
- Six-dimensional dynamic tractography atlas of language connectivity in the developing brain.Brain : a journal of neurology · 2021Article
- Graph theoretical analysis of evoked potentials shows network influence of epileptogenic mesial temporal region.Human brain mapping · 2021Article
- Four-dimensional tractography animates propagations of neural activation via distinct interhemispheric pathways.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2021Article
- Spatial-Temporal Functional Mapping Combined With Cortico-Cortical Evoked Potentials in Predicting Cortical Stimulation Results.Frontiers in human neuroscience · 2021Article
- Consciousness and complexity: a consilience of evidence.Neuroscience of consciousness · 2021Review
- Effects of depth electrode montage and single-pulse electrical stimulation sites on neuronal responses and effective connectivity.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2020Article
- Brain-scale cortico-cortical functional connectivity in the delta-theta band is a robust signature of conscious states: an intracranial and scalp EEG study.Scientific reports · 2020Article
- Article
Corrections and comments
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Authors and funding
14 authors at 2 institutions in 2 countries.
Funding
Abstract
Wakefulness and sleep arise from global changes in brain physiology that may also govern the flow of neural activity between cortical regions responsible for perceptual processing versus planning and action. To test whether and how the sleep/wake cycle affects the overall propagation of neural activity in large-scale brain networks, we applied single-pulse electrical stimulation (SPES) in patients implanted with intracranial EEG electrodes for epilepsy surgery. SPES elicited cortico-cortical spectral responses at high-gamma frequencies (CCSRHG, 80-150 Hz), which indexes changes in neuronal population firing rates. Using event-related causality (ERC) analysis, we found that the overall patterns of neural propagation among sites with CCSRHG were different during wakefulness and different sleep stages. For example, stimulation of frontal lobe elicited greater propagation toward parietal lobe during slow-wave sleep than during wakefulness. During REM sleep, we observed a decrease in propagation within frontal lobe, and an increase in propagation within parietal lobe, elicited by frontal and parietal stimulation, respectively. These biases in the directionality of large-scale cortical network dynamics during REM sleep could potentially account for some of the unique experiential aspects of this sleep stage. Together these findings suggest that the regulation of conscious awareness and sleep is associated with differences in the balance of neural propagation across large-scale frontal-parietal networks.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.