ArticleeLife2019
Optogenetically induced low-frequency correlations impair perception.
Article in eLife, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed.
- Optogenetic Manipulation of Covert Attention in the Nonhuman Primate.Journal of cognitive neuroscience · 2025Article
- Brain-state mediated modulation of inter-laminar dependencies in visual cortex.Nature communications · 2024Article
- Article
- Endogenous fluctuations in cortical state selectively enhance different modes of sensory processing in human temporal lobe.Nature communications · 2023Article
- Cortical VIP neurons locally control the gain but globally control the coherence of gamma band rhythms.Neuron · 2023Article
- Behavioral optogenetics in nonhuman primates; a psychological perspective.Current research in neurobiology · 2023Review
- Review
- Pop-out search instigates beta-gated feature selectivity enhancement across V4 layers.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Spontaneous traveling waves naturally emerge from horizontal fiber time delays and travel through locally asynchronous-irregular states.Nature communications · 2021Article
- Diminished Cortical Excitation and Elevated Inhibition During Perceptual Impairments in a Mouse Model of Autism.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- An Open Resource for Non-human Primate Optogenetics.Neuron · 2020Article
- Neuromodulation of Brain State and Behavior.Annual review of neuroscience · 2020Review
- An Ultra-Sensitive Step-Function Opsin for Minimally Invasive Optogenetic Stimulation in Mice and Macaques.Neuron · 2020Article
- Fast and reversible neural inactivation in macaque cortex by optogenetic stimulation of GABAergic neurons.eLife · 2020Article
- Article
- The asynchronous state's relation to large-scale potentials in cortex.Journal of neurophysiology · 2019Review
- Article
Corrections and comments
- Erratum issued
Authors and funding
4 authors.
Funding
Abstract
Deployment of covert attention to a spatial location can cause large decreases in low-frequency correlated variability among neurons in macaque area V4 whose receptive-fields lie at the attended location. It has been estimated that this reduction accounts for a substantial fraction of the attention-mediated improvement in sensory processing. These estimates depend on assumptions about how population signals are decoded and the conclusion that correlated variability impairs perception, is purely hypothetical. Here we test this proposal directly by optogenetically inducing low-frequency fluctuations, to see if this interferes with performance in an attention-demanding task. We find that low-frequency optical stimulation of neurons in V4 elevates correlations among pairs of neurons and impairs the animal's ability to make fine sensory discriminations. Stimulation at higher frequencies does not impair performance, despite comparable modulation of neuronal responses. These results support the hypothesis that attention-dependent reductions in correlated variability contribute to improved perception of attended stimuli.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.