ArticleInternational journal of stroke : official journal of the International Stroke Society2020
Ligature-induced periodontitis induces systemic inflammation but does not alter acute outcome after stroke in mice.
Article in International journal of stroke : official journal of the International Stroke Society, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- The effect of stroke on the bone mineral density: A systematic review and meta-analysis.The journal of nutrition, health & aging · 2024Pooled it
- Unveiling the Impact ofJournal of the American Heart Association · 2026Article
- The bidirectional effects and mechanisms of the oral and gut microbiomes: a narrative review.Frontiers in immunology · 2026Review
- Association between Alzheimer's disease andWorld journal of biological chemistry · 2025Article
- Osteoporosis and stroke: a bidirectional mendelian randomization study.Journal of bone and mineral metabolism · 2025Article
- Therapeutic Potential of Extracellular Vesicles in Oral Inflammation.International journal of molecular sciences · 2025Review
- Oral Microbiome Dysbiosis as a Risk Factor for Stroke: A Comprehensive Review.Microorganisms · 2024Review
- Oral Health in Patients Hospitalized Because of Ischemic Stroke.Journal of clinical medicine · 2024Article
- Interaction of periodontal clinical indicators in metabolic syndrome and nonalcoholic fatty liver disease: Implications for preventive interventions.The Saudi dental journal · 2024Article
- Neutrophils' Contribution to Periodontitis and Periodontitis-Associated Cardiovascular Diseases.International journal of molecular sciences · 2023Review
- Systemic antibiotics increase microbiota pathogenicity and oral bone loss.International journal of oral science · 2023Article
- The Influence of Periodontal Diseases and the Stimulation of Saliva Secretion on the Course of the Acute Phase of Ischemic Stroke.Journal of clinical medicine · 2022Article
- Local induction of regulatory T cells prevents inflammatory bone loss in ligature-induced experimental periodontitis in mice.Scientific reports · 2022Article
- Novel Insight into the Mechanisms of the Bidirectional Relationship between Diabetes and Periodontitis.Biomedicines · 2022Review
- Periodontopathic Microbiota and Atherosclerosis: Roles of TLR-Mediated Inflammation Response.Oxidative medicine and cellular longevity · 2022Review
- Application of Ligature-Induced Periodontitis in Mice to Explore the Molecular Mechanism of Periodontal Disease.International journal of molecular sciences · 2021Review
- Local and systemic mechanisms linking periodontal disease and inflammatory comorbidities.Nature reviews. Immunology · 2021Review
- Serum IgG titers to periodontal pathogens predict 3-month outcome in ischemic stroke patients.PloS one · 2020Article
- Distal Consequences of Oral Inflammation.Frontiers in immunology · 2019Review
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
backgroundStroke is a major cause of disability and mortality. Poorer outcome after stroke is associated with concomitant inflammatory and infectious disease. Periodontitis is a chronic inflammatory disease of the dental supporting structures and is a prominent risk factor for many systemic disorders, including cardiovascular disease and stroke. While epidemiological studies suggest that periodontitis increases the likelihood of stroke, its impact on stroke severity is poorly understood. Here, we sought to determine the contribution of periodontitis to acute stroke pathology.
methodsWe characterized a murine ligature model of periodontitis for inflammatory responses that could potentially impact stroke outcome. We applied this model and then subjected mice to either transient or permanent middle cerebral artery occlusion. We also enhanced the periodontitis model with repeated intravenous administration of a periodontal-specific lipopolysaccharide to better mimic the clinical condition.
resultsLigature-induced periodontitis caused bone loss, bacterial growth, and increased local inflammatory cell trafficking. Systemically, periodontitis increased circulating levels of pro-inflammatory cytokines, and primed bone marrow monocytes to produce elevated tumour necrosis factor-alpha (TNFα). Despite these changes, periodontitis alone or in tandem with repeated lipopolysaccharide challenge did not alter infarct volume, blood-brain barrier breakdown, or systemic inflammation after experimental stroke.
conclusionsOur data show that despite elevated systemic inflammation in periodontitis, oral inflammatory disease does not impact acute stroke pathology in terms of severity, determined primarily by infarct volume. This indicates that, at least in this experimental paradigm, periodontitis alone does not alter acute outcome after cerebral ischemia.
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