Evidence map›Paper›PMID 30794026›Full record

ArticleJournal of neurotrauma2019

Diazepam Inhibits Post-Traumatic Neurogenesis and Blocks Aberrant Dendritic Development.

Laura E Villasana, Austin Peters, Raluca McCallum, Chang Liu, Eric Schnell

Open access · greenAbstract read
In one paragraph

Article in Journal of neurotrauma, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Lipocalin-2 Is a Key Regulator of Neuroinflammation in Secondary Traumatic and Ischemic Brain Injury.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2023
    Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Laura E Villasana1Department of Anesthesiology and Perioperative Medicine, Oregon Health & Science University, Portland, Oregon.
Austin Peters1Department of Anesthesiology and Perioperative Medicine, Oregon Health & Science University, Portland, Oregon.
Raluca McCallum2Operative Care Division, VA Portland Health Care System, Portland, Oregon.
Chang Liu1Department of Anesthesiology and Perioperative Medicine, Oregon Health & Science University, Portland, Oregon.
Eric Schnell1Department of Anesthesiology and Perioperative Medicine, Oregon Health & Science University, Portland, Oregon.
Oregon Health & Science University · USVA Portland Health Care System · US

Funding

Scholars in Women's Health Research Across the LifespanK12HD043488 · NICHD · OREGON HEALTH & SCIENCE UNIVERSITY · PI MYATT, LESLIE · 2002 to 2023
$10.4M
Ultrastructure and Single Particle Microscopy CoreP30NS061800 · NINDS · OREGON HEALTH & SCIENCE UNIVERSITY · PI AICHER, SUE A · 2009 to 2020
$6.6M
Oregon Clinical and Translational Research InstituteTL1TR000129 · NCATS · OREGON HEALTH & SCIENCE UNIVERSITY · PI ELLISON, DAVID H · 2012 to 2015
$613k
Integrated and Translational Training in Anesthesiology ResearchT32GM082770 · NIGMS · OREGON HEALTH & SCIENCE UNIVERSITY · PI KIRSCH, JEFFREY R · 2008 to 2012
$471k
Synaptic integration of newborn neurons after traumatic brain injuryF32NS083109 · NINDS · OREGON HEALTH & SCIENCE UNIVERSITY · PI VILLASANA, LAURA E. · 2013 to 2015
$78k
Functional contribution of adult-born neurons to epileptogenesisI01BX002949 · VA · PORTLAND VA MEDICAL CENTER · PI SCHNELL, ERIC · 2016 to 2019
–
BLRD VA I01 BX002949NCATS NIH HHS TL1 TR000129NICHD NIH HHS K12 HD043488NIGMS NIH HHS T32 GM082770NINDS NIH HHS F32 NS083109NINDS NIH HHS P30 NS061800
6 · The paper itself

Abstract

Traumatic brain injury (TBI) triggers a robust increase in neurogenesis within the dentate gyrus of the hippocampus, but these new neurons undergo aberrant maturation and dendritic outgrowth. Because gamma-aminobutyric acid (GABA)

Indexed as

AnimalsBrain InjuriesCell MovementCell ProliferationCell ShapeDendritesDiazepamDisease Models, AnimalGABA ModulatorsHippocampusMiceNeurogenesisNeuronsRecovery of FunctionDiazepamGABA Modulatorscontrolled cortical impactdiazepammodels of injuryneurogenesisregenerationtraumatic brain injury

Identifiers

PMID30794026
PMCPMC6661923
OpenAlexW2915358810

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.