Evidence map›Paper›PMID 30793871›Full record

ArticleProteomics2019

On the Need to Develop Guidelines for Characterizing and Reporting Intrinsic Disorder in Proteins.

Michael Vincent, Vladimir N Uversky, Santiago Schnell

Abstract read
In one paragraph

Article in Proteomics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Michael VincentInterdisciplinary Biological Sciences, Northwestern University, Evanston, IL, 60208, USA.
Vladimir N UverskyDepartment of Molecular Medicine and USF Health Byrd Alzheimer's Research Institute, Morsani College of Medicine, University of South Florida, Tampa, Florida, 33612, USA.ORCID 0000-0002-4037-5857
Santiago SchnellDepartment of Molecular & Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan, 48109, USA.ORCID 0000-0002-9477-3914

Funding

Mediators of mitophagy in the regulation of beta cell functionR01DK108921 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SOLEIMANPOUR, SCOTT · 2016 to 2020
$1.9M
NIDDK NIH HHS R01 DK108921
6 · The paper itself

Abstract

Since the early 2000s, numerous computational tools have been created and used to predict intrinsic disorder in proteins. At present, the output from these algorithms is difficult to interpret in the absence of standards or references for comparison. There are many reasons to establish a set of standard-based guidelines to evaluate computational protein disorder predictions. This viewpoint explores a handful of these reasons, including standardizing nomenclature to improve communication, rigor and reproducibility, and making it easier for newcomers to enter the field. An approach for reporting predicted disorder in single proteins with respect to whole proteomes is discussed. The suggestions are not intended to be formulaic; they should be viewed as a starting point to establish guidelines for interpreting and reporting computational protein disorder predictions.

Indexed as

Amino Acid SequenceAnimalsDatabases, ProteinHumansIntrinsically Disordered ProteinsProtein ConformationProteomicsIntrinsically Disordered Proteinsbioinformaticscomputational biologyintrinsically disordered proteinsprotein sequencesprotein structuresproteomics

Identifiers

PMID30793871
PMCPMC6571172

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.