Evidence map›Paper›PMID 30793830›Full record

ArticleChembiochem : a European journal of chemical biology2019

A Retro-biosynthesis-Based Route to Generate Pinene-Derived Polyesters.

Arne Stamm, Antonino Biundo, Björn Schmidt, Jörg Brücher, Stefan Lundmark, Peter Olsén, Linda Fogelström, Eva Malmström, Uwe T Bornscheuer, Per-Olof Syrén

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chembiochem : a European journal of chemical biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.9field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. A Retro-biosynthesis-Based Route to Generate Pinene-Derived Polyesters.Chembiochem : a European journal of chemical biology · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 2 countries.

Arne StammKTH Royal Institute of Technology, School of Engineering Sciences in Chemistry, Biotechnology and Health, Department of Fibre and Polymer Technology, Teknikringen 56-58, 100 44, Stockholm, Sweden.
Antonino BiundoKTH Royal Institute of Technology, School of Engineering Sciences in Chemistry, Biotechnology and Health, Department of Fibre and Polymer Technology, Teknikringen 56-58, 100 44, Stockholm, Sweden.
Björn SchmidtKTH Royal Institute of Technology, School of Engineering Sciences in Chemistry, Biotechnology and Health, Department of Fibre and Polymer Technology, Teknikringen 56-58, 100 44, Stockholm, Sweden.
Jörg BrücherHolmen AB, Development, 89180, Östersund, Sweden.
Stefan LundmarkPerstorp AB, Innovation, Perstorp Industrial Park, 284 80, Perstorp, Sweden.
Peter OlsénKTH Royal Institute of Technology, School of Engineering Sciences in Chemistry, Biotechnology and Health, Department of Fibre and Polymer Technology, Teknikringen 56-58, 100 44, Stockholm, Sweden.
Linda FogelströmKTH Royal Institute of Technology, School of Engineering Sciences in Chemistry, Biotechnology and Health, Department of Fibre and Polymer Technology, Teknikringen 56-58, 100 44, Stockholm, Sweden.
Eva MalmströmKTH Royal Institute of Technology, School of Engineering Sciences in Chemistry, Biotechnology and Health, Department of Fibre and Polymer Technology, Teknikringen 56-58, 100 44, Stockholm, Sweden.
Uwe T BornscheuerDepartment of Biotechnology and Enzyme Catalysis, Institute of Biochemistry, Universität Greifswald, Felix-Hausdorff-Strasse 4, 17487, Greifswald, Germany.
Per-Olof SyrénKTH Royal Institute of Technology, School of Engineering Sciences in Chemistry, Biotechnology and Health, Department of Fibre and Polymer Technology, Teknikringen 56-58, 100 44, Stockholm, Sweden.ORCID 0000-0002-4066-2776
Science for Life Laboratory · SEWallenberg Wood Science Center · SEKTH Royal Institute of Technology · SEÖstersunds Hospital · SEPerstorp (Sweden) · SEUniversität Greifswald · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Significantly increased production of biobased polymers is a prerequisite to replace petroleum-based materials towards reaching a circular bioeconomy. However, many renewable building blocks from wood and other plant material are not directly amenable for polymerization, due to their inert backbones and/or lack of functional group compatibility with the desired polymerization type. Based on a retro-biosynthetic analysis of polyesters, a chemoenzymatic route from (-)-α-pinene towards a verbanone-based lactone, which is further used in ring-opening polymerization, is presented. Generated pinene-derived polyesters showed elevated degradation and glass transition temperatures, compared with poly(ϵ-decalactone), which lacks a ring structure in its backbone. Semirational enzyme engineering of the cyclohexanone monooxygenase from Acinetobacter calcoaceticus enabled the biosynthesis of the key lactone intermediate for the targeted polyester. As a proof of principle, one enzyme variant identified from screening in a microtiter plate was used in biocatalytic upscaling, which afforded the bicyclic lactone in 39 % conversion in shake flask scale reactions.

Indexed as

AnimalsBicyclic MonoterpenesCatalaseCattleEscherichia coliGlucose 1-DehydrogenaseMixed Function OxygenasesPolyestersPolymerizationalpha-pineneBicyclic MonoterpenesCatalaseGlucose 1-DehydrogenaseMixed Function OxygenasesPolyestersbiopolymersenzymeslactonesretrosynthesisterpene

Identifiers

PMID30793830
PMCPMC6618282
OpenAlexW2915228852

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.